Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 14102..14703 | Replicon | chromosome |
Accession | NZ_CP090908 | ||
Organism | Serratia marcescens strain Sys06 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0P0Q8I8 |
Locus tag | L1F17_RS00070 | Protein ID | WP_004933929.1 |
Coordinates | 14102..14482 (-) | Length | 127 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A086G6A0 |
Locus tag | L1F17_RS00075 | Protein ID | WP_004933932.1 |
Coordinates | 14482..14703 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1F17_RS00045 (L1F17_00045) | 9348..10628 | + | 1281 | WP_049278441.1 | DUF3748 domain-containing protein | - |
L1F17_RS00050 (L1F17_00050) | 10659..11006 | - | 348 | WP_004933911.1 | YceK/YidQ family lipoprotein | - |
L1F17_RS00055 (L1F17_00055) | 11316..11729 | + | 414 | WP_004933919.1 | small heat shock chaperone IbpA | - |
L1F17_RS00060 (L1F17_00060) | 11837..12265 | + | 429 | WP_004933922.1 | small heat shock chaperone IbpB | - |
L1F17_RS00065 (L1F17_00065) | 12433..14091 | + | 1659 | WP_033631397.1 | putative transporter | - |
L1F17_RS00070 (L1F17_00070) | 14102..14482 | - | 381 | WP_004933929.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
L1F17_RS00075 (L1F17_00075) | 14482..14703 | - | 222 | WP_004933932.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
L1F17_RS00080 (L1F17_00080) | 14778..16028 | - | 1251 | WP_060558016.1 | valine--pyruvate transaminase | - |
L1F17_RS00085 (L1F17_00085) | 16164..18227 | - | 2064 | WP_033631398.1 | alpha-amylase | - |
L1F17_RS00090 (L1F17_00090) | 18423..18575 | + | 153 | WP_015376155.1 | hypothetical protein | - |
L1F17_RS00095 (L1F17_00095) | 18577..19554 | - | 978 | WP_060558018.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14173.48 Da Isoelectric Point: 7.3170
>T232083 WP_004933929.1 NZ_CP090908:c14482-14102 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL
Download Length: 381 bp
>T232083 NZ_CP127252:923637-923810 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8593.53 Da Isoelectric Point: 4.4791
>AT232083 WP_004933932.1 NZ_CP090908:c14703-14482 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE
Download Length: 222 bp
>AT232083 NZ_CP127252:923313-923609 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0P0Q8I8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A086G6A0 |