Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14102..14703 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0Q8I8
Locus tag L1F17_RS00070 Protein ID WP_004933929.1
Coordinates 14102..14482 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag L1F17_RS00075 Protein ID WP_004933932.1
Coordinates 14482..14703 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS00045 (L1F17_00045) 9348..10628 + 1281 WP_049278441.1 DUF3748 domain-containing protein -
L1F17_RS00050 (L1F17_00050) 10659..11006 - 348 WP_004933911.1 YceK/YidQ family lipoprotein -
L1F17_RS00055 (L1F17_00055) 11316..11729 + 414 WP_004933919.1 small heat shock chaperone IbpA -
L1F17_RS00060 (L1F17_00060) 11837..12265 + 429 WP_004933922.1 small heat shock chaperone IbpB -
L1F17_RS00065 (L1F17_00065) 12433..14091 + 1659 WP_033631397.1 putative transporter -
L1F17_RS00070 (L1F17_00070) 14102..14482 - 381 WP_004933929.1 type II toxin-antitoxin system VapC family toxin Toxin
L1F17_RS00075 (L1F17_00075) 14482..14703 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
L1F17_RS00080 (L1F17_00080) 14778..16028 - 1251 WP_060558016.1 valine--pyruvate transaminase -
L1F17_RS00085 (L1F17_00085) 16164..18227 - 2064 WP_033631398.1 alpha-amylase -
L1F17_RS00090 (L1F17_00090) 18423..18575 + 153 WP_015376155.1 hypothetical protein -
L1F17_RS00095 (L1F17_00095) 18577..19554 - 978 WP_060558018.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14173.48 Da        Isoelectric Point: 7.3170

>T232083 WP_004933929.1 NZ_CP090908:c14482-14102 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T232083 NZ_CP127252:923637-923810 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT232083 WP_004933932.1 NZ_CP090908:c14703-14482 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT232083 NZ_CP127252:923313-923609 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0Q8I8

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References