Detailed information of TA system TA232079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 755609..756174
• Replicon: chromosome
• Accession: NZ_CP090898
• Organism: Synechococcus sp. NB0720_010

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: LY254_RS04110
• Protein ID: WP_247479090.1
• Coordinates: 755839..756174 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: LY254_RS04105
• Protein ID: WP_247479088.1
• Coordinates: 755609..755845 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LY254_RS04085 (LY254_04085)	750938..751825	-	888	WP_247479080.1	phosphatidate cytidylyltransferase	-
LY254_RS04090 (LY254_04090)	751822..752436	-	615	WP_247479082.1	precorrin-6Y C5,15-methyltransferase subunit CbiT	-
LY254_RS04095 (LY254_04095)	752445..753842	-	1398	WP_247479084.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
LY254_RS04100 (LY254_04100)	753874..755526	+	1653	WP_247479086.1	AarF/ABC1/UbiB kinase family protein	-
LY254_RS04105 (LY254_04105)	755609..755845	+	237	WP_247479088.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LY254_RS04110 (LY254_04110)	755839..756174	+	336	WP_247479090.1	endoribonuclease MazF	Toxin
LY254_RS04115 (LY254_04115)	756200..756667	+	468	WP_247479092.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-102)

Antitoxin

• SpoVT-AbrB domain (8-47)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12069.91 Da
• Isoelectric Point: 9.7589

>T232079 WP_247479090.1 NZ_CP090898:755839-756174 [Synechococcus sp. NB0720_010]
MVSAPERGDLIWLSFTPQQGREQAGRRPALVISPAAYNSKTGLALVCPITSKAKGYPFEVVLPNQGTVQGVVLTDQLRSL
DWRARQAERIEKSPPDVVDQAVKLIGTLLTS

Nucleotide

• Length: 336 bp

>T232079 NZ_CP127244:c4046271-4046089 [Salinicola sp. JS01]
GTGAAAAGCAGAGACCTGATCAAGGAGTTGGAAGCCGATGGCTGGGTACTGGACCGCATCCGAGGTAGCCACCACGTCTT
CAAACACCCAACGAAGCCAGGAGCCGTGCCGGTTCCTCACCCCAAGAAGGACATGAAGATCGGCACGATCAACGCCATCA
GGAAACAAGCCGGGCTCAAGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8429.49 Da
• Isoelectric Point: 4.5489

>AT232079 WP_247479088.1 NZ_CP090898:755609-755845 [Synechococcus sp. NB0720_010]
MRVKVQAWGNSLGLRIPKAYASELGVRAGSEMEVSVEAGALRAELAPPAQLDALLAKITDENRHDQIEWGEPSGGETW

Nucleotide

• Length: 237 bp

>AT232079 NZ_CP127244:c4046050-4045640 [Salinicola sp. JS01]
ATGCAATATCCGATCGCCATCGATTGGGGCGACGACACCCACGCCACCGGTATCGTCTTCCCCGACATTCCCGGCGCCAT
CACCGCCGGCGACAGCGTCGCTCACGCCTATGAAATGGCGGTGGAGGTCGCCCATATCCAGCTCGAGGAGCTGGTCAGCG
CCGGCCAGCCGATCCCCAAGCCGGGCAGCATCGAGCAGCACCGCCAAAACCCCGACTTCGAGGGCTGGGGTTGGGGGTTG
GTCGAGATCGACGTCACGCCCTACCTGGGCAAGACCGAAAAGGTCAACGTCACCCTGCCCGGAACGCTGGTCAAGCGAAT
CGACGACTATGTCAGCCTCCACGGCATCAAGAGCCGTTCGGCCTTTCTGGCGTCCGCCGCGCTCCACGAACTGGAGCATC
GCTCCCGCTGA