Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1621434..1623070 Replicon chromosome
Accession NZ_CP090890
Organism Acinetobacter junii strain WCO-9

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag L0U97_RS07560 Protein ID WP_234856037.1
Coordinates 1621739..1623070 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag L0U97_RS07555 Protein ID WP_004911089.1
Coordinates 1621434..1621742 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0U97_RS07530 1616672..1617901 - 1230 WP_004954432.1 GGDEF domain-containing protein -
L0U97_RS07535 1618245..1618991 + 747 WP_234856034.1 iron-containing redox enzyme family protein -
L0U97_RS07540 1619058..1619756 - 699 WP_234856035.1 NAD(P)H-dependent oxidoreductase -
L0U97_RS07545 1619881..1620879 + 999 WP_234856036.1 AraC family transcriptional regulator -
L0U97_RS07550 1621105..1621356 + 252 WP_125298717.1 VF530 family protein -
L0U97_RS07555 1621434..1621742 - 309 WP_004911089.1 helix-turn-helix transcriptional regulator Antitoxin
L0U97_RS07560 1621739..1623070 - 1332 WP_234856037.1 HipA domain-containing protein Toxin
L0U97_RS07565 1623348..1624046 + 699 WP_125298719.1 DUF1826 domain-containing protein -
L0U97_RS07570 1624106..1624903 - 798 WP_234856038.1 sulfite exporter TauE/SafE family protein -
L0U97_RS07575 1624945..1625439 - 495 WP_005402649.1 flavin reductase -
L0U97_RS07580 1625639..1626667 - 1029 WP_004911103.1 methionine synthase -
L0U97_RS07585 1626691..1627686 - 996 WP_004954402.1 DUF1852 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-365)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-82)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50662.35 Da        Isoelectric Point: 5.2120

>T232075 WP_234856037.1 NZ_CP090890:c1623070-1621739 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYDLEYAIHNLDKRDEHACSLSLPIQILIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSHSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRHGLESVYSVLNKASGSHLNHFEVIENLCNLLISIDSEFDSAQFVCEWLQRDLL
NTIFGNSDNHGRNTSFLKQSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWEQITQKLAHLCDPNLSLTTLK
SLASHLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T232075 NZ_CP127239:c1534-1268 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11674.61 Da        Isoelectric Point: 9.9970

>AT232075 WP_004911089.1 NZ_CP090890:c1621742-1621434 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYLQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp

>AT232075 NZ_CP127239:c1742-1518 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References