232074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1610560..1611228 Replicon chromosome
Accession NZ_CP090889
Organism Streptococcus pneumoniae strain CH2439

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag L1A13_RS08240 Protein ID WP_001132285.1
Coordinates 1611049..1611228 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4J1XUY0
Locus tag L1A13_RS08235 Protein ID WP_000961812.1
Coordinates 1610560..1611012 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A13_RS08210 (L1A13_08210) 1606450..1607193 - 744 WP_001188204.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
L1A13_RS08215 (L1A13_08215) 1607195..1608145 - 951 WP_000451160.1 50S ribosomal protein L11 methyltransferase -
L1A13_RS08220 (L1A13_08220) 1608283..1608711 - 429 WP_000418157.1 NUDIX hydrolase -
L1A13_RS08225 (L1A13_08225) 1608692..1609780 - 1089 WP_000719712.1 site-2 protease family protein -
L1A13_RS08230 (L1A13_08230) 1609799..1610269 - 471 WP_000257088.1 DUF3013 family protein -
L1A13_RS08235 (L1A13_08235) 1610560..1611012 - 453 WP_000961812.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1A13_RS08240 (L1A13_08240) 1611049..1611228 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
L1A13_RS08245 (L1A13_08245) 1611365..1611613 - 249 WP_000797237.1 hypothetical protein -
L1A13_RS08250 (L1A13_08250) 1611603..1611842 - 240 WP_000818079.1 hypothetical protein -
L1A13_RS08255 (L1A13_08255) 1612112..1613383 + 1272 WP_001113213.1 replication-associated recombination protein A -
L1A13_RS08265 (L1A13_08265) 1613803..1614930 - 1128 WP_000323403.1 tyrosine-type recombinase/integrase -
L1A13_RS08270 (L1A13_08270) 1614932..1615114 - 183 WP_000655518.1 DUF3173 domain-containing protein -
L1A13_RS08275 (L1A13_08275) 1615130..1616173 - 1044 WP_001031659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T232074 WP_001132285.1 NZ_CP090889:c1611228-1611049 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T232074 NZ_CP127238:c9189-8875 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT232074 WP_000961812.1 NZ_CP090889:c1611012-1610560 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGLTVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT232074 NZ_CP127238:c9455-9177 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1XUY0

References