Detailed information of TA system TA232070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1120490..1120988
• Replicon: chromosome
• Accession: NZ_CP090888
• Organism: Streptococcus pneumoniae strain PT8465

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L1A19_RS05565
• Protein ID: WP_001812387.1
• Coordinates: 1120490..1120744 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: L1A19_RS05570
• Protein ID: WP_000208080.1
• Coordinates: 1120746..1120988 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A19_RS05550 (L1A19_05550)	1115751..1118219	-	2469	WP_001152997.1	DNA gyrase subunit A	-
L1A19_RS05555 (L1A19_05555)	1118413..1119399	+	987	WP_000204733.1	L-lactate dehydrogenase	-
L1A19_RS05560 (L1A19_05560)	1119748..1120443	-	696	WP_000731127.1	potassium channel family protein	-
L1A19_RS05565 (L1A19_05565)	1120490..1120744	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1A19_RS05570 (L1A19_05570)	1120746..1120988	-	243	WP_000208080.1	DUF6290 family protein	Antitoxin
L1A19_RS05575 (L1A19_05575)	1121079..1121888	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
L1A19_RS05580 (L1A19_05580)	1121890..1123239	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
L1A19_RS05585 (L1A19_05585)	1123232..1123936	-	705	WP_000722076.1	response regulator YycF	-
L1A19_RS05590 (L1A19_05590)	1123991..1125166	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T232070 WP_001812387.1 NZ_CP090888:c1120744-1120490 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T232070 NZ_CP127236:c148635-148219 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT232070 WP_000208080.1 NZ_CP090888:c1120988-1120746 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT232070 NZ_CP127236:c148862-148632 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7