Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1615702..1616370 Replicon chromosome
Accession NZ_CP090887
Organism Streptococcus pneumoniae strain NP7536

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag L1A18_RS08160 Protein ID WP_001132284.1
Coordinates 1616191..1616370 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag L1A18_RS08155 Protein ID WP_000961810.1
Coordinates 1615702..1616154 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A18_RS08130 (L1A18_08130) 1611592..1612335 - 744 WP_001188199.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
L1A18_RS08135 (L1A18_08135) 1612337..1613287 - 951 WP_000451132.1 50S ribosomal protein L11 methyltransferase -
L1A18_RS08140 (L1A18_08140) 1613425..1613853 - 429 WP_000418176.1 NUDIX hydrolase -
L1A18_RS08145 (L1A18_08145) 1613819..1614922 - 1104 WP_000719717.1 site-2 protease family protein -
L1A18_RS08150 (L1A18_08150) 1614941..1615411 - 471 WP_000257106.1 DUF3013 family protein -
L1A18_RS08155 (L1A18_08155) 1615702..1616154 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1A18_RS08160 (L1A18_08160) 1616191..1616370 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
L1A18_RS08165 (L1A18_08165) 1616507..1616686 - 180 WP_001809903.1 hypothetical protein -
L1A18_RS08170 (L1A18_08170) 1616851..1617090 - 240 WP_000818078.1 hypothetical protein -
L1A18_RS08175 (L1A18_08175) 1617360..1618631 + 1272 WP_001113196.1 replication-associated recombination protein A -
L1A18_RS08185 (L1A18_08185) 1619176..1620495 - 1320 WP_000502545.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T232068 WP_001132284.1 NZ_CP090887:c1616370-1616191 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T232068 NZ_CP127235:c5379744-5379361 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT232068 WP_000961810.1 NZ_CP090887:c1616154-1615702 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT232068 NZ_CP127235:c5379986-5379744 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References