Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | zeta-pezA/zeta-couple_hipB |
| Location | 1082402..1083636 | Replicon | chromosome |
| Accession | NZ_CP090887 | ||
| Organism | Streptococcus pneumoniae strain NP7536 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | B6ZCC3 |
| Locus tag | L1A18_RS05410 | Protein ID | WP_000405371.1 |
| Coordinates | 1082878..1083636 (+) | Length | 253 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCC4 |
| Locus tag | L1A18_RS05405 | Protein ID | WP_000579612.1 |
| Coordinates | 1082402..1082878 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A18_RS05380 (L1A18_05380) | 1077512..1077760 | + | 249 | WP_001814254.1 | hypothetical protein | - |
| L1A18_RS05385 (L1A18_05385) | 1077931..1078650 | + | 720 | Protein_1070 | type A chloramphenicol O-acetyltransferase | - |
| L1A18_RS05390 (L1A18_05390) | 1079446..1080369 | - | 924 | WP_074189357.1 | protein rep | - |
| L1A18_RS05395 (L1A18_05395) | 1080573..1081403 | + | 831 | Protein_1072 | alpha-amylase family glycosyl hydrolase | - |
| L1A18_RS05400 (L1A18_05400) | 1081671..1082126 | + | 456 | WP_025173603.1 | hypothetical protein | - |
| L1A18_RS05405 (L1A18_05405) | 1082402..1082878 | + | 477 | WP_000579612.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| L1A18_RS05410 (L1A18_05410) | 1082878..1083636 | + | 759 | WP_000405371.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| L1A18_RS05415 (L1A18_05415) | 1083900..1084583 | + | 684 | WP_000492702.1 | LexA family transcriptional regulator | - |
| L1A18_RS05420 (L1A18_05420) | 1084586..1086001 | + | 1416 | WP_000219662.1 | Y-family DNA polymerase | - |
| L1A18_RS05425 (L1A18_05425) | 1086001..1086363 | + | 363 | WP_001082151.1 | hypothetical protein | - |
| L1A18_RS05430 (L1A18_05430) | 1086353..1086643 | + | 291 | WP_001080183.1 | DUF5960 family protein | - |
| L1A18_RS05435 (L1A18_05435) | 1086938..1087294 | + | 357 | WP_000827835.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| L1A18_RS05440 (L1A18_05440) | 1087299..1087664 | + | 366 | WP_000401236.1 | MobC family plasmid mobilization relaxosome protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(M) / cat(pC194) | - | 1045507..1091904 | 46397 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 253 a.a. Molecular weight: 28812.66 Da Isoelectric Point: 8.0883
>T232066 WP_000405371.1 NZ_CP090887:1082878-1083636 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYSGLQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHYLLFGEWNQVEKEML
KSGEERLKDLTN
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYSGLQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHYLLFGEWNQVEKEML
KSGEERLKDLTN
Download Length: 759 bp
>T232066 NZ_CP127235:c4899376-4899092 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18245.68 Da Isoelectric Point: 4.4188
>AT232066 WP_000579612.1 NZ_CP090887:1082402-1082878 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT232066 NZ_CP127235:c4899608-4899366 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|