Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | zeta-pezA/zeta-couple_hipB |
| Location | 1534214..1535460 | Replicon | chromosome |
| Accession | NZ_CP090886 | ||
| Organism | Streptococcus pneumoniae strain NP7513 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | L1A17_RS07970 | Protein ID | WP_000405370.1 |
| Coordinates | 1534214..1534984 (-) | Length | 257 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCC4 |
| Locus tag | L1A17_RS07975 | Protein ID | WP_000579612.1 |
| Coordinates | 1534984..1535460 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A17_RS07940 (L1A17_07940) | 1530194..1530559 | - | 366 | WP_000401236.1 | MobC family plasmid mobilization relaxosome protein | - |
| L1A17_RS07945 (L1A17_07945) | 1530564..1530920 | - | 357 | WP_000827835.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| L1A17_RS07950 (L1A17_07950) | 1531215..1531505 | - | 291 | WP_001080184.1 | DUF5960 family protein | - |
| L1A17_RS07955 (L1A17_07955) | 1531495..1531857 | - | 363 | WP_001082151.1 | hypothetical protein | - |
| L1A17_RS07960 (L1A17_07960) | 1531857..1533272 | - | 1416 | WP_000118333.1 | Y-family DNA polymerase | - |
| L1A17_RS07965 (L1A17_07965) | 1533275..1533958 | - | 684 | WP_000492698.1 | LexA family transcriptional regulator | - |
| L1A17_RS07970 (L1A17_07970) | 1534214..1534984 | - | 771 | WP_000405370.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| L1A17_RS07975 (L1A17_07975) | 1534984..1535460 | - | 477 | WP_000579612.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| L1A17_RS07980 (L1A17_07980) | 1535736..1536191 | - | 456 | WP_025173603.1 | hypothetical protein | - |
| L1A17_RS07985 (L1A17_07985) | 1536459..1537289 | - | 831 | Protein_1532 | alpha-amylase family glycosyl hydrolase | - |
| L1A17_RS07990 (L1A17_07990) | 1537491..1538336 | + | 846 | WP_000366623.1 | protein rep | - |
| L1A17_RS07995 (L1A17_07995) | 1539132..1539851 | - | 720 | Protein_1534 | type A chloramphenicol O-acetyltransferase | - |
| L1A17_RS08000 (L1A17_08000) | 1540022..1540270 | - | 249 | WP_001814254.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | cat(pC194) | - | 1521725..1544604 | 22879 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 257 a.a. Molecular weight: 29282.22 Da Isoelectric Point: 7.9592
>T232061 WP_000405370.1 NZ_CP090886:c1534984-1534214 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVNNTRQLEELAIFERIQIYQRDRSCVYDSGEDKTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGC
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVNNTRQLEELAIFERIQIYQRDRSCVYDSGEDKTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGC
Download Length: 771 bp
>T232061 NZ_CP127235:856341-856748 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18245.68 Da Isoelectric Point: 4.4188
>AT232061 WP_000579612.1 NZ_CP090886:c1535460-1534984 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT232061 NZ_CP127235:856094-856360 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|