Detailed information of TA system TA232060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1467340..1467838
• Replicon: chromosome
• Accession: NZ_CP090886
• Organism: Streptococcus pneumoniae strain NP7513

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L1A17_RS07635
• Protein ID: WP_001812387.1
• Coordinates: 1467584..1467838 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: L1A17_RS07630
• Protein ID: WP_000208080.1
• Coordinates: 1467340..1467582 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A17_RS07610 (L1A17_07610)	1463162..1464337	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
L1A17_RS07615 (L1A17_07615)	1464392..1465096	+	705	WP_000722076.1	response regulator YycF	-
L1A17_RS07620 (L1A17_07620)	1465089..1466438	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
L1A17_RS07625 (L1A17_07625)	1466440..1467249	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
L1A17_RS07630 (L1A17_07630)	1467340..1467582	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
L1A17_RS07635 (L1A17_07635)	1467584..1467838	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1A17_RS07640 (L1A17_07640)	1467885..1468580	+	696	WP_000731127.1	potassium channel family protein	-
L1A17_RS07645 (L1A17_07645)	1468929..1469915	-	987	WP_000204733.1	L-lactate dehydrogenase	-
L1A17_RS07650 (L1A17_07650)	1470109..1472577	+	2469	WP_001152997.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T232060 WP_001812387.1 NZ_CP090886:1467584-1467838 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T232060 NZ_CP127235:720879-721364 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT232060 WP_000208080.1 NZ_CP090886:1467340-1467582 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT232060 NZ_CP127235:720589-720882 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7