Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1001696..1002364 Replicon chromosome
Accession NZ_CP090886
Organism Streptococcus pneumoniae strain NP7513

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag L1A17_RS05220 Protein ID WP_001132284.1
Coordinates 1001696..1001875 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag L1A17_RS05225 Protein ID WP_000961810.1
Coordinates 1001912..1002364 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A17_RS05195 (L1A17_05195) 997571..998890 + 1320 WP_000502545.1 glycoside hydrolase family 32 protein -
L1A17_RS05205 (L1A17_05205) 999435..1000706 - 1272 WP_001113196.1 replication-associated recombination protein A -
L1A17_RS05210 (L1A17_05210) 1000976..1001215 + 240 WP_000818078.1 hypothetical protein -
L1A17_RS05215 (L1A17_05215) 1001380..1001559 + 180 WP_001809903.1 hypothetical protein -
L1A17_RS05220 (L1A17_05220) 1001696..1001875 + 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
L1A17_RS05225 (L1A17_05225) 1001912..1002364 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1A17_RS05230 (L1A17_05230) 1002655..1003125 + 471 WP_000257106.1 DUF3013 family protein -
L1A17_RS05235 (L1A17_05235) 1003144..1004247 + 1104 WP_000719717.1 site-2 protease family protein -
L1A17_RS05240 (L1A17_05240) 1004213..1004641 + 429 WP_000418176.1 NUDIX hydrolase -
L1A17_RS05245 (L1A17_05245) 1004779..1005729 + 951 WP_000451132.1 50S ribosomal protein L11 methyltransferase -
L1A17_RS05250 (L1A17_05250) 1005731..1006474 + 744 WP_001188199.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T232059 WP_001132284.1 NZ_CP090886:1001696-1001875 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T232059 NZ_CP127235:353992-354339 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT232059 WP_000961810.1 NZ_CP090886:1001912-1002364 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT232059 NZ_CP127235:354339-354638 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References