Detailed information of TA system TA232057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1149183..1149681
• Replicon: chromosome
• Accession: NZ_CP090885
• Organism: Streptococcus pneumoniae strain ND6401

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L1A16_RS05760
• Protein ID: WP_001812387.1
• Coordinates: 1149183..1149437 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: L1A16_RS05765
• Protein ID: WP_000208080.1
• Coordinates: 1149439..1149681 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A16_RS05745 (L1A16_05745)	1144444..1146912	-	2469	WP_001152997.1	DNA gyrase subunit A	-
L1A16_RS05750 (L1A16_05750)	1147106..1148092	+	987	WP_000204733.1	L-lactate dehydrogenase	-
L1A16_RS05755 (L1A16_05755)	1148441..1149136	-	696	WP_000731127.1	potassium channel family protein	-
L1A16_RS05760 (L1A16_05760)	1149183..1149437	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1A16_RS05765 (L1A16_05765)	1149439..1149681	-	243	WP_000208080.1	DUF6290 family protein	Antitoxin
L1A16_RS05770 (L1A16_05770)	1149772..1150581	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
L1A16_RS05775 (L1A16_05775)	1150583..1151932	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
L1A16_RS05780 (L1A16_05780)	1151925..1152629	-	705	WP_000722076.1	response regulator YycF	-
L1A16_RS05785 (L1A16_05785)	1152684..1153859	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T232057 WP_001812387.1 NZ_CP090885:c1149437-1149183 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T232057 NZ_CP127234:828-1094 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT232057 WP_000208080.1 NZ_CP090885:c1149681-1149439 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT232057 NZ_CP127234:620-844 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7