Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | zeta-pezA/zeta-couple_hipB |
| Location | 1081547..1082781 | Replicon | chromosome |
| Accession | NZ_CP090885 | ||
| Organism | Streptococcus pneumoniae strain ND6401 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | B6ZCC3 |
| Locus tag | L1A16_RS05425 | Protein ID | WP_000405371.1 |
| Coordinates | 1082023..1082781 (+) | Length | 253 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCC4 |
| Locus tag | L1A16_RS05420 | Protein ID | WP_000579612.1 |
| Coordinates | 1081547..1082023 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A16_RS05395 (L1A16_05395) | 1076657..1076905 | + | 249 | WP_001814254.1 | hypothetical protein | - |
| L1A16_RS05400 (L1A16_05400) | 1077076..1077795 | + | 720 | Protein_1076 | type A chloramphenicol O-acetyltransferase | - |
| L1A16_RS05405 (L1A16_05405) | 1078591..1079514 | - | 924 | WP_074189357.1 | protein rep | - |
| L1A16_RS05410 (L1A16_05410) | 1079718..1080548 | + | 831 | Protein_1078 | alpha-amylase family glycosyl hydrolase | - |
| L1A16_RS05415 (L1A16_05415) | 1080816..1081271 | + | 456 | WP_025172307.1 | hypothetical protein | - |
| L1A16_RS05420 (L1A16_05420) | 1081547..1082023 | + | 477 | WP_000579612.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| L1A16_RS05425 (L1A16_05425) | 1082023..1082781 | + | 759 | WP_000405371.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| L1A16_RS05430 (L1A16_05430) | 1083045..1083728 | + | 684 | WP_000492702.1 | LexA family transcriptional regulator | - |
| L1A16_RS05435 (L1A16_05435) | 1083731..1085146 | + | 1416 | WP_000219662.1 | Y-family DNA polymerase | - |
| L1A16_RS05440 (L1A16_05440) | 1085146..1085508 | + | 363 | WP_001082151.1 | hypothetical protein | - |
| L1A16_RS05445 (L1A16_05445) | 1085498..1085788 | + | 291 | WP_001080183.1 | DUF5960 family protein | - |
| L1A16_RS05450 (L1A16_05450) | 1086083..1086439 | + | 357 | WP_000827835.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| L1A16_RS05455 (L1A16_05455) | 1086444..1086809 | + | 366 | WP_000401236.1 | MobC family plasmid mobilization relaxosome protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1080627..1091049 | 10422 | |
| - | inside | Integrative and Conjugative Element | erm(B) / tet(M) / cat(pC194) | - | 1019245..1080376 | 61131 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 253 a.a. Molecular weight: 28812.66 Da Isoelectric Point: 8.0883
>T232056 WP_000405371.1 NZ_CP090885:1082023-1082781 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYSGLQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHYLLFGEWNQVEKEML
KSGEERLKDLTN
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYSGLQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHYLLFGEWNQVEKEML
KSGEERLKDLTN
Download Length: 759 bp
>T232056 NZ_CP127233:c3807-3493 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18245.68 Da Isoelectric Point: 4.4188
>AT232056 WP_000579612.1 NZ_CP090885:1081547-1082023 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT232056 NZ_CP127233:c4073-3795 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|