Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 1073920..1075154 | Replicon | chromosome |
| Accession | NZ_CP090885 | ||
| Organism | Streptococcus pneumoniae strain ND6401 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | B6ZCD1 |
| Locus tag | L1A16_RS05385 | Protein ID | WP_000354294.1 |
| Coordinates | 1074396..1075154 (+) | Length | 253 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCD2 |
| Locus tag | L1A16_RS05380 | Protein ID | WP_000579617.1 |
| Coordinates | 1073920..1074396 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A16_RS05340 (L1A16_05340) | 1070177..1070461 | + | 285 | WP_000969646.1 | DUF5962 family protein | - |
| L1A16_RS05345 (L1A16_05345) | 1070475..1070771 | + | 297 | WP_000998894.1 | DUF5966 family protein | - |
| L1A16_RS05350 (L1A16_05350) | 1070785..1070982 | - | 198 | WP_001841477.1 | hypothetical protein | - |
| L1A16_RS05355 (L1A16_05355) | 1071142..1071783 | + | 642 | WP_000933083.1 | hypothetical protein | - |
| L1A16_RS05360 (L1A16_05360) | 1071793..1072878 | + | 1086 | WP_000401901.1 | toprim domain-containing protein | - |
| L1A16_RS05365 (L1A16_05365) | 1072929..1073162 | + | 234 | WP_000152419.1 | DUF5965 family protein | - |
| L1A16_RS05370 (L1A16_05370) | 1073159..1073542 | + | 384 | WP_000159222.1 | DUF5945 family protein | - |
| L1A16_RS05375 (L1A16_05375) | 1073580..1073852 | + | 273 | WP_000495438.1 | hypothetical protein | - |
| L1A16_RS05380 (L1A16_05380) | 1073920..1074396 | + | 477 | WP_000579617.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| L1A16_RS05385 (L1A16_05385) | 1074396..1075154 | + | 759 | WP_000354294.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| L1A16_RS05390 (L1A16_05390) | 1075630..1076418 | + | 789 | WP_000214003.1 | hypothetical protein | - |
| L1A16_RS05395 (L1A16_05395) | 1076657..1076905 | + | 249 | WP_001814254.1 | hypothetical protein | - |
| L1A16_RS05400 (L1A16_05400) | 1077076..1077795 | + | 720 | Protein_1076 | type A chloramphenicol O-acetyltransferase | - |
| L1A16_RS05405 (L1A16_05405) | 1078591..1079514 | - | 924 | WP_074189357.1 | protein rep | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(B) / tet(M) / cat(pC194) | - | 1019245..1080376 | 61131 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 253 a.a. Molecular weight: 28929.87 Da Isoelectric Point: 7.5458
>T232055 WP_000354294.1 NZ_CP090885:1074396-1075154 [Streptococcus pneumoniae]
MDIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
MDIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
Download Length: 759 bp
>T232055 NZ_CP127231:102223-102705 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18286.74 Da Isoelectric Point: 4.4977
>AT232055 WP_000579617.1 NZ_CP090885:1073920-1074396 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDNRGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDNRGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT232055 NZ_CP127231:101969-102235 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|