Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1611008..1611676 Replicon chromosome
Accession NZ_CP090883
Organism Streptococcus pneumoniae strain LE4448

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag L1A14_RS08245 Protein ID WP_001132285.1
Coordinates 1611497..1611676 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4J1XUY0
Locus tag L1A14_RS08240 Protein ID WP_000961812.1
Coordinates 1611008..1611460 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A14_RS08215 (L1A14_08215) 1606898..1607641 - 744 WP_001188204.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
L1A14_RS08220 (L1A14_08220) 1607643..1608593 - 951 WP_000451160.1 50S ribosomal protein L11 methyltransferase -
L1A14_RS08225 (L1A14_08225) 1608731..1609159 - 429 WP_000418157.1 NUDIX hydrolase -
L1A14_RS08230 (L1A14_08230) 1609140..1610228 - 1089 WP_000719712.1 site-2 protease family protein -
L1A14_RS08235 (L1A14_08235) 1610247..1610717 - 471 WP_000257088.1 DUF3013 family protein -
L1A14_RS08240 (L1A14_08240) 1611008..1611460 - 453 WP_000961812.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1A14_RS08245 (L1A14_08245) 1611497..1611676 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
L1A14_RS08250 (L1A14_08250) 1611813..1612061 - 249 WP_000797237.1 hypothetical protein -
L1A14_RS08255 (L1A14_08255) 1612051..1612290 - 240 WP_000818079.1 hypothetical protein -
L1A14_RS08260 (L1A14_08260) 1612560..1613831 + 1272 WP_001113213.1 replication-associated recombination protein A -
L1A14_RS08270 (L1A14_08270) 1614251..1615378 - 1128 WP_000323403.1 tyrosine-type recombinase/integrase -
L1A14_RS08275 (L1A14_08275) 1615380..1615562 - 183 WP_000655518.1 DUF3173 domain-containing protein -
L1A14_RS08280 (L1A14_08280) 1615578..1616621 - 1044 WP_001031659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T232050 WP_001132285.1 NZ_CP090883:c1611676-1611497 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T232050 NZ_CP127229:4324027-4324129 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT232050 WP_000961812.1 NZ_CP090883:c1611460-1611008 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGLTVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT232050 NZ_CP127229:c4324136-4323991 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1XUY0

References