23205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1594120..1594758 Replicon chromosome
Accession NC_011415
Organism Escherichia coli SE11

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ECSE_RS07870 Protein ID WP_000813794.1
Coordinates 1594120..1594296 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ECSE_RS07875 Protein ID WP_001270285.1
Coordinates 1594342..1594758 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSE_RS07850 1589739..1590953 - 1215 WP_077626012.1 BenE family transporter YdcO -
ECSE_RS07855 1591006..1591542 + 537 WP_000429153.1 DNA-binding transcriptional regulator SutR -
ECSE_RS07860 1591615..1593576 + 1962 WP_024210448.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ECSE_RS07865 1593668..1593898 - 231 WP_000494244.1 YncJ family protein -
ECSE_RS07870 1594120..1594296 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ECSE_RS07875 1594342..1594758 + 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ECSE_RS07880 1594837..1596243 + 1407 WP_000760589.1 PLP-dependent aminotransferase family protein -
ECSE_RS07885 1596488..1597633 + 1146 WP_000034363.1 ABC transporter substrate-binding protein -
ECSE_RS07890 1597651..1598664 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
ECSE_RS07895 1598665..1599606 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1588551..1589699 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T23205 WP_000813794.1 NC_011415:1594120-1594296 [Escherichia coli SE11]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T23205 NC_011415:1594120-1594296 [Escherichia coli SE11]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT23205 WP_001270285.1 NC_011415:1594342-1594758 [Escherichia coli SE11]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT23205 NC_011415:1594342-1594758 [Escherichia coli SE11]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References