Detailed information of TA system TA232049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1147443..1147941
• Replicon: chromosome
• Accession: NZ_CP090883
• Organism: Streptococcus pneumoniae strain LE4448

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L1A14_RS05840
• Protein ID: WP_001812387.1
• Coordinates: 1147443..1147697 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: L1A14_RS05845
• Protein ID: WP_000208080.1
• Coordinates: 1147699..1147941 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A14_RS05825 (L1A14_05825)	1142704..1145172	-	2469	WP_001152997.1	DNA gyrase subunit A	-
L1A14_RS05830 (L1A14_05830)	1145366..1146352	+	987	WP_000204733.1	L-lactate dehydrogenase	-
L1A14_RS05835 (L1A14_05835)	1146701..1147396	-	696	WP_000731127.1	potassium channel family protein	-
L1A14_RS05840 (L1A14_05840)	1147443..1147697	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1A14_RS05845 (L1A14_05845)	1147699..1147941	-	243	WP_000208080.1	DUF6290 family protein	Antitoxin
L1A14_RS05850 (L1A14_05850)	1148032..1148841	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
L1A14_RS05855 (L1A14_05855)	1148843..1150192	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
L1A14_RS05860 (L1A14_05860)	1150185..1150889	-	705	WP_000722076.1	response regulator YycF	-
L1A14_RS05865 (L1A14_05865)	1150944..1152119	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T232049 WP_001812387.1 NZ_CP090883:c1147697-1147443 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T232049 NZ_CP127229:3179470-3179877 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT232049 WP_000208080.1 NZ_CP090883:c1147941-1147699 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT232049 NZ_CP127229:3179223-3179489 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7