Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1615332..1616000 Replicon chromosome
Accession NZ_CP090882
Organism Streptococcus pneumoniae strain CH2241

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag L1A12_RS08155 Protein ID WP_001132284.1
Coordinates 1615821..1616000 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag L1A12_RS08150 Protein ID WP_000961810.1
Coordinates 1615332..1615784 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A12_RS08125 (L1A12_08125) 1611222..1611965 - 744 WP_001188199.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
L1A12_RS08130 (L1A12_08130) 1611967..1612917 - 951 WP_000451132.1 50S ribosomal protein L11 methyltransferase -
L1A12_RS08135 (L1A12_08135) 1613055..1613483 - 429 WP_000418176.1 NUDIX hydrolase -
L1A12_RS08140 (L1A12_08140) 1613449..1614552 - 1104 WP_000719717.1 site-2 protease family protein -
L1A12_RS08145 (L1A12_08145) 1614571..1615041 - 471 WP_000257106.1 DUF3013 family protein -
L1A12_RS08150 (L1A12_08150) 1615332..1615784 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1A12_RS08155 (L1A12_08155) 1615821..1616000 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
L1A12_RS08160 (L1A12_08160) 1616137..1616316 - 180 WP_001809903.1 hypothetical protein -
L1A12_RS08165 (L1A12_08165) 1616481..1616720 - 240 WP_000818078.1 hypothetical protein -
L1A12_RS08170 (L1A12_08170) 1616990..1618261 + 1272 WP_001113196.1 replication-associated recombination protein A -
L1A12_RS08180 (L1A12_08180) 1618806..1620125 - 1320 WP_000502545.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T232047 WP_001132284.1 NZ_CP090882:c1616000-1615821 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T232047 NZ_CP127229:2632451-2632819 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT232047 WP_000961810.1 NZ_CP090882:c1615784-1615332 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT232047 NZ_CP127229:2632233-2632454 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References