Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 1073156..1074390 | Replicon | chromosome |
| Accession | NZ_CP090882 | ||
| Organism | Streptococcus pneumoniae strain CH2241 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | B6ZCD1 |
| Locus tag | L1A12_RS05360 | Protein ID | WP_000354294.1 |
| Coordinates | 1073632..1074390 (+) | Length | 253 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCD2 |
| Locus tag | L1A12_RS05355 | Protein ID | WP_000579617.1 |
| Coordinates | 1073156..1073632 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A12_RS05315 (L1A12_05315) | 1069413..1069697 | + | 285 | WP_000969646.1 | DUF5962 family protein | - |
| L1A12_RS05320 (L1A12_05320) | 1069711..1070007 | + | 297 | WP_000998894.1 | DUF5966 family protein | - |
| L1A12_RS05325 (L1A12_05325) | 1070021..1070218 | - | 198 | WP_001841477.1 | hypothetical protein | - |
| L1A12_RS05330 (L1A12_05330) | 1070378..1071019 | + | 642 | WP_000933083.1 | hypothetical protein | - |
| L1A12_RS05335 (L1A12_05335) | 1071029..1072114 | + | 1086 | WP_000401901.1 | toprim domain-containing protein | - |
| L1A12_RS05340 (L1A12_05340) | 1072165..1072398 | + | 234 | WP_000152419.1 | DUF5965 family protein | - |
| L1A12_RS05345 (L1A12_05345) | 1072395..1072778 | + | 384 | WP_000159222.1 | DUF5945 family protein | - |
| L1A12_RS05350 (L1A12_05350) | 1072816..1073088 | + | 273 | WP_000495438.1 | hypothetical protein | - |
| L1A12_RS05355 (L1A12_05355) | 1073156..1073632 | + | 477 | WP_000579617.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| L1A12_RS05360 (L1A12_05360) | 1073632..1074390 | + | 759 | WP_000354294.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| L1A12_RS05365 (L1A12_05365) | 1074866..1075654 | + | 789 | WP_000214003.1 | hypothetical protein | - |
| L1A12_RS05370 (L1A12_05370) | 1075893..1076141 | + | 249 | WP_001814254.1 | hypothetical protein | - |
| L1A12_RS05375 (L1A12_05375) | 1076312..1077031 | + | 720 | Protein_1068 | type A chloramphenicol O-acetyltransferase | - |
| L1A12_RS05380 (L1A12_05380) | 1077827..1078750 | - | 924 | WP_074189357.1 | protein rep | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(B) / tet(M) / cat(pC194) | - | 1018481..1079612 | 61131 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 253 a.a. Molecular weight: 28929.87 Da Isoelectric Point: 7.5458
>T232044 WP_000354294.1 NZ_CP090882:1073632-1074390 [Streptococcus pneumoniae]
MDIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
MDIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
Download Length: 759 bp
>T232044 NZ_CP127229:c1747722-1747438 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18286.74 Da Isoelectric Point: 4.4977
>AT232044 WP_000579617.1 NZ_CP090882:1073156-1073632 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDNRGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDNRGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT232044 NZ_CP127229:c1747954-1747712 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|