Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 913894..915131 Replicon chromosome
Accession NZ_CP090882
Organism Streptococcus pneumoniae strain CH2241

Toxin (Protein)


Gene name pezT Uniprot ID A0A4J1ZCF4
Locus tag L1A12_RS04600 Protein ID WP_000405368.1
Coordinates 914370..915131 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag L1A12_RS04595 Protein ID WP_000579602.1
Coordinates 913894..914370 (+) Length 159 a.a.

Genomic Context


L1A12_RS04575L1A12_RS04580L1A12_RS04585L1A12_RS04590L1A12_RS04595L1A12_RS04600L1A12_RS04605L1A12_RS04610L1A12_RS04615L1A12_RS04620
Location: 908967..909821 (855 bp)
Type: Others
Protein ID: WP_000900019.1
Location: 909933..910817 (885 bp)
Type: Others
Protein ID: WP_000710115.1
Location: 910980..912719 (1740 bp)
Type: Others
Protein ID: WP_000423464.1
Location: 912994..913449 (456 bp)
Type: Others
Protein ID: WP_000500478.1
Location: 913894..914370 (477 bp)
Type: Antitoxin
Protein ID: WP_000579602.1
Location: 914370..915131 (762 bp)
Type: Toxin
Protein ID: WP_000405368.1
Location: 915159..916316 (1158 bp)
Type: Others
Protein ID: WP_001213951.1
Location: 917148..917507 (360 bp)
Type: Others
Protein ID: WP_000529545.1
Location: 917517..917882 (366 bp)
Type: Others
Protein ID: WP_000263039.1
Location: 917869..919719 (1851 bp)
Type: Others
Protein ID: Protein_917
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
L1A12_RS04575 (L1A12_04575)908967..909821+855WP_000900019.1ADP-ribosylglycohydrolase family protein-
L1A12_RS04580 (L1A12_04580)909933..910817+885WP_000710115.1diacylglycerol kinase family lipid kinase-
L1A12_RS04585 (L1A12_04585)910980..912719+1740WP_000423464.1glycoside hydrolase family 13 protein-
L1A12_RS04590 (L1A12_04590)912994..913449+456WP_000500478.1hypothetical protein-
L1A12_RS04595 (L1A12_04595)913894..914370+477WP_000579602.1type II toxin-antitoxin system antitoxin PezAAntitoxin
L1A12_RS04600 (L1A12_04600)914370..915131+762WP_000405368.1type II toxin-antitoxin system toxin PezTToxin
L1A12_RS04605 (L1A12_04605)915159..916316+1158WP_001213951.1hypothetical protein-
L1A12_RS04610 (L1A12_04610)917148..917507+360WP_000529545.1SAG1252 family conjugative relaxosome accessory protein-
L1A12_RS04615 (L1A12_04615)917517..917882+366WP_000263039.1plasmid mobilization relaxosome protein MobC-
L1A12_RS04620 (L1A12_04620)917869..919719+1851Protein_917SAG1250 family conjugative relaxase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-215)

Antitoxin

(3-60)


Sequences


Toxin        


Download         Length: 254 a.a.        Molecular weight: 29185.27 Da        Isoelectric Point: 7.5090

>T232043 WP_000405368.1 NZ_CP090882:914370-915131 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFVGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVGEKRLNELLEK

Download         Length: 762 bp

>T232043 NZ_CP127229:c1645390-1644857 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18289.70 Da        Isoelectric Point: 4.4188

>AT232043 WP_000579602.1 NZ_CP090882:913894-914370 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT232043 NZ_CP127229:c1645667-1645401 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A4J1ZCF4


Antitoxin

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Source
ID
Structure
No matching records found

References