Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
Location | 913894..915131 | Replicon | chromosome |
Accession | NZ_CP090882 | ||
Organism | Streptococcus pneumoniae strain CH2241 |
Toxin (Protein)
Gene name | pezT | Uniprot ID | A0A4J1ZCF4 |
Locus tag | L1A12_RS04600 | Protein ID | WP_000405368.1 |
Coordinates | 914370..915131 (+) | Length | 254 a.a. |
Antitoxin (Protein)
Gene name | pezA | Uniprot ID | - |
Locus tag | L1A12_RS04595 | Protein ID | WP_000579602.1 |
Coordinates | 913894..914370 (+) | Length | 159 a.a. |
Genomic Context
Location: 908967..909821 (855 bp)
Type: Others
Protein ID: WP_000900019.1
Type: Others
Protein ID: WP_000900019.1
Location: 909933..910817 (885 bp)
Type: Others
Protein ID: WP_000710115.1
Type: Others
Protein ID: WP_000710115.1
Location: 910980..912719 (1740 bp)
Type: Others
Protein ID: WP_000423464.1
Type: Others
Protein ID: WP_000423464.1
Location: 912994..913449 (456 bp)
Type: Others
Protein ID: WP_000500478.1
Type: Others
Protein ID: WP_000500478.1
Location: 913894..914370 (477 bp)
Type: Antitoxin
Protein ID: WP_000579602.1
Type: Antitoxin
Protein ID: WP_000579602.1
Location: 914370..915131 (762 bp)
Type: Toxin
Protein ID: WP_000405368.1
Type: Toxin
Protein ID: WP_000405368.1
Location: 915159..916316 (1158 bp)
Type: Others
Protein ID: WP_001213951.1
Type: Others
Protein ID: WP_001213951.1
Location: 917148..917507 (360 bp)
Type: Others
Protein ID: WP_000529545.1
Type: Others
Protein ID: WP_000529545.1
Location: 917517..917882 (366 bp)
Type: Others
Protein ID: WP_000263039.1
Type: Others
Protein ID: WP_000263039.1
Location: 917869..919719 (1851 bp)
Type: Others
Protein ID: Protein_917
Type: Others
Protein ID: Protein_917
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1A12_RS04575 (L1A12_04575) | 908967..909821 | + | 855 | WP_000900019.1 | ADP-ribosylglycohydrolase family protein | - |
L1A12_RS04580 (L1A12_04580) | 909933..910817 | + | 885 | WP_000710115.1 | diacylglycerol kinase family lipid kinase | - |
L1A12_RS04585 (L1A12_04585) | 910980..912719 | + | 1740 | WP_000423464.1 | glycoside hydrolase family 13 protein | - |
L1A12_RS04590 (L1A12_04590) | 912994..913449 | + | 456 | WP_000500478.1 | hypothetical protein | - |
L1A12_RS04595 (L1A12_04595) | 913894..914370 | + | 477 | WP_000579602.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
L1A12_RS04600 (L1A12_04600) | 914370..915131 | + | 762 | WP_000405368.1 | type II toxin-antitoxin system toxin PezT | Toxin |
L1A12_RS04605 (L1A12_04605) | 915159..916316 | + | 1158 | WP_001213951.1 | hypothetical protein | - |
L1A12_RS04610 (L1A12_04610) | 917148..917507 | + | 360 | WP_000529545.1 | SAG1252 family conjugative relaxosome accessory protein | - |
L1A12_RS04615 (L1A12_04615) | 917517..917882 | + | 366 | WP_000263039.1 | plasmid mobilization relaxosome protein MobC | - |
L1A12_RS04620 (L1A12_04620) | 917869..919719 | + | 1851 | Protein_917 | SAG1250 family conjugative relaxase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 254 a.a. Molecular weight: 29185.27 Da Isoelectric Point: 7.5090
>T232043 WP_000405368.1 NZ_CP090882:914370-915131 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFVGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVGEKRLNELLEK
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFVGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVGEKRLNELLEK
Download Length: 762 bp
>T232043 NZ_CP127229:c1645390-1644857 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18289.70 Da Isoelectric Point: 4.4188
>AT232043 WP_000579602.1 NZ_CP090882:913894-914370 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT232043 NZ_CP127229:c1645667-1645401 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4J1ZCF4 |
Antitoxin
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Source | ID | Structure |
---|---|---|
No matching records found |