Detailed information of TA system TA232040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1009734..1010971
• Replicon: chromosome
• Accession: NZ_CP090881
• Organism: Streptococcus pneumoniae strain BR1268

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J1ZCF4
• Locus tag: L1A11_RS05245
• Protein ID: WP_000405368.1
• Coordinates: 1010210..1010971 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: L1A11_RS05240
• Protein ID: WP_000579602.1
• Coordinates: 1009734..1010210 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A11_RS05220 (L1A11_05220)	1004807..1005661	+	855	WP_000900019.1	ADP-ribosylglycohydrolase family protein	-
L1A11_RS05225 (L1A11_05225)	1005773..1006657	+	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
L1A11_RS05230 (L1A11_05230)	1006820..1008559	+	1740	WP_000423464.1	glycoside hydrolase family 13 protein	-
L1A11_RS05235 (L1A11_05235)	1008834..1009289	+	456	WP_000500478.1	hypothetical protein	-
L1A11_RS05240 (L1A11_05240)	1009734..1010210	+	477	WP_000579602.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
L1A11_RS05245 (L1A11_05245)	1010210..1010971	+	762	WP_000405368.1	type II toxin-antitoxin system toxin PezT	Toxin
L1A11_RS05250 (L1A11_05250)	1010999..1012156	+	1158	WP_001213951.1	hypothetical protein	-
L1A11_RS05255 (L1A11_05255)	1012988..1013347	+	360	WP_000529545.1	SAG1252 family conjugative relaxosome accessory protein	-
L1A11_RS05260 (L1A11_05260)	1013357..1013722	+	366	WP_000263039.1	plasmid mobilization relaxosome protein MobC	-
L1A11_RS05265 (L1A11_05265)	1013709..1015559	+	1851	Protein_1034	SAG1250 family conjugative relaxase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	994478..1039950	45472

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29185.27 Da
• Isoelectric Point: 7.5090

>T232040 WP_000405368.1 NZ_CP090881:1010210-1010971 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFVGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T232040 NZ_CP127228:5826082-5826834 [Pseudomonas tohonis]
ATGGATATCTGGACGACCTGCCAGGGCCCGCAACACGTCGGGCCCCTGCGTGGCCGCCTGGTGCGCTTGGTGGAGAGCCA
GGAGCAGGTGGCGACCCTGCAGCTGGTGGACAACCTCGCCGAACAGGCGTTGCTGGAGGAACTCATCGAGACCAGCAAGC
CGCCGTTGCCCAGGAGCGCCGAGCCGCTGCACTACCTGCTCAAGACCCCGTTCCGCTACCCGCCGCTGCGCTGGGGGTCG
CGCTTCGGCACCGTCCACGAGCCGAGCCTGTTCTACGCCGCCTCGCGCCTGGAGACCGCCATGGCCGAGGGGGCGTTCTA
CCGCTTCGTCCTGTGGAGCGGCATGGCCGTGCCGCCCCCCAGCGGGCGCATCCTTTCCGAGCATTCCTCCTTCGAGGCGC
GTTTCCAGGTGGAGCGTGGCGTGCAGCTGCAATTGCCACCGTTCGATCGTCACGCTCAAGCGCTGGCCGACCCGGTGGAC
TACCGCGCCAGCCAGGCGCTCGGCGCGGCCATGCGTGCCGCAGGCGTGGAGGCCTTCGAGTACCGCTCCGCGCGCTGCCC
GCTGCAGGGCACCAATATCGCCCTGTTCACCCCCGAGGCCTTCACCGAGCGGCGGCCACGCAACCTCACGCCCTGGCTCT
GCGAGACCACCGCCGAGTACGTCGCCTTCAAGCATGCCCAGGCGCCGGATACGCCGCGCCTGTTCCGCATGACGCAATTC
CTGATCGACGGCCACCTGCCACAGCCGGCATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18289.70 Da
• Isoelectric Point: 4.4188

>AT232040 WP_000579602.1 NZ_CP090881:1009734-1010210 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT232040 NZ_CP127228:5825675-5826046 [Pseudomonas tohonis]
ATGAGCGCCCTCAGCCGTCCCACTCTCGATCCCGATGCCGTCCTGGCCAAGGCCCTGCTCAATACCCGCGAGCAACTCGG
GCTGACCCAGCAGCAACTGGCCGACATCGTCGGTGTGCACCGCACCGCCATCACCCGCTGGGCGGACAGCGGCGGCATCC
GTCCGCAGAGCAAGACCGGCGAGCTCGCGCTGCTGCTGATCCGCGCCTACCGCGCATTGTTCGCCCTGTTCGGCGGCAAC
CTCGACGACATGCGCCACTTCCTGCGCACCGAGAACCGCCACCTGGGCGCCGTTCCCCTCGAACTGATGGGCCAGGTGCA
GGGTCTGGTGAGGGTGGTGGAGTACCTGGACGCCATACGCGGCAAGATCTGA

Structures

Toxin

• AlphaFold DB: A0A4J1ZCF4