Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2017313..2018089 Replicon chromosome
Accession NZ_CP090879
Organism Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag L1A04_RS10130 Protein ID WP_000031108.1
Coordinates 2017937..2018089 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag L1A04_RS10125 Protein ID WP_001251219.1
Coordinates 2017313..2017912 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A04_RS10105 (2013229) 2013229..2014686 + 1458 WP_000649898.1 ABC transporter permease subunit -
L1A04_RS10110 (2014679) 2014679..2015401 + 723 WP_033845135.1 amino acid ABC transporter ATP-binding protein -
L1A04_RS10115 (2015552) 2015552..2016679 + 1128 WP_234877949.1 tRNA epoxyqueuosine(34) reductase QueG -
L1A04_RS10120 (2016684) 2016684..2017154 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
L1A04_RS10125 (2017313) 2017313..2017912 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
L1A04_RS10130 (2017937) 2017937..2018089 + 153 WP_000031108.1 SAS053 family protein Toxin
L1A04_RS10135 (2018690) 2018690..2019085 + 396 WP_000901019.1 hypothetical protein -
L1A04_RS10140 (2019281) 2019281..2020666 + 1386 WP_000116227.1 class II fumarate hydratase -
L1A04_RS10145 (2021122) 2021122..2021943 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T232037 WP_000031108.1 NZ_CP090879:2017937-2018089 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T232037 NZ_CP127228:c1586134-1585550 [Pseudomonas tohonis]
ATGAACATCGACATCATCAGGGCGCGGCTCGACTTCCTGCGTGAGGCGGAGCGCCTCAAGGATGTGCTGCGCAGCGCCCA
CACCTCTTCCGGGCGGGCGGAAAGCACCGCCGAGCACAGCTGGCGCCTGTGCCTGATGGCCATCACCTTCGCCGACGAGC
TGGCCGGGCTCGACCTGCTGCGGGTGCTGAAGATGTGCGTGGTGCACGACCTGGGCGAGGCCATCCATGGCGACATCCCC
GCCGTCGAGCAGGGCGGCCACCCCGACAAGGGGGCCCAGGAGCGCGAGGACCTGCTGACCCTGACCCGCACCCTGGACGA
TGGGCTGCGCGGGGAGATCCTCGCGCTGTGGGACGACTACGAGAACGCCGCCTCCCCAGAGGCGCTGGCGGTCAAGGCGC
TGGACAAGCTGGAGACCCTGCTGCAGCACACCCAGGGCGCCAACCCGGAGGACTTCGACTACGCCTTCAACCTCGGCTAC
GGGCGCCGCTACACCAGCGGCGAACCGCTGTTCGCGGCCATCCGTGCACAGCTGGACGAGGACACGAGGCGGCGGATGGA
GGCGCAGGCAAGCGTACCTCGCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT232037 WP_001251219.1 NZ_CP090879:2017313-2017912 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT232037 NZ_CP127228:c1586803-1586246 [Pseudomonas tohonis]
ATGCACGACAGCCTCCCGAAACCGGTCTCGCTCGGCCTCGCGCTGCGCCGTTGGCGCCTGTTGCACCGGGTGAAGCAGGC
CCACGCCGCGCAGCTGTTCGGCGTCGCCCAGTCGACCATCTCGCGCTGGGAAAGCGGGGCGCAGGCGATGGAGCCGGCCG
AGCGCGCGCGGGTGGAGCAGGTGCTTGGCGCCCGGCTGGAGGCGGCGGCCGACCAGGCCCTGGCGCGGCTGGTGGGCGAC
AGCCCGCGCGCGGTGCACCTGGTCTGCGACCTGAGCCATCGCCTGCTGGCCTGTTCCGCCCTGCGCGCCGCCGAATTCAG
CGTGCCCCTCTCCGAGCTGCTGGGCCGCTCGCTGTGGCGCTACGCGACGCCGGAGATCGTGCGCCAGGAGGACGCGCTGG
ACGCCCTGGGCTGGCGCGACGTGCTGATGCCGCCGGCGCTGGAGTTCGGCAGCGGCAGCAACGAGTCCGCCATCGTGCCG
ATCCGCCAGGGCCTGTGCCGCTGGACGCGCATGACGCTTTCCGACGGCACCGCTGCGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References