Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tsbAT/- |
| Location | 2017313..2018089 | Replicon | chromosome |
| Accession | NZ_CP090879 | ||
| Organism | Staphylococcus aureus strain SAUR_BFS2 | ||
Toxin (Protein)
| Gene name | tsbT | Uniprot ID | X5E2E6 |
| Locus tag | L1A04_RS10130 | Protein ID | WP_000031108.1 |
| Coordinates | 2017937..2018089 (+) | Length | 51 a.a. |
Antitoxin (Protein)
| Gene name | tsbA | Uniprot ID | A0A0D1IYN8 |
| Locus tag | L1A04_RS10125 | Protein ID | WP_001251219.1 |
| Coordinates | 2017313..2017912 (+) | Length | 200 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A04_RS10105 (2013229) | 2013229..2014686 | + | 1458 | WP_000649898.1 | ABC transporter permease subunit | - |
| L1A04_RS10110 (2014679) | 2014679..2015401 | + | 723 | WP_033845135.1 | amino acid ABC transporter ATP-binding protein | - |
| L1A04_RS10115 (2015552) | 2015552..2016679 | + | 1128 | WP_234877949.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
| L1A04_RS10120 (2016684) | 2016684..2017154 | + | 471 | WP_000181394.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
| L1A04_RS10125 (2017313) | 2017313..2017912 | + | 600 | WP_001251219.1 | glucosamine-6-phosphate isomerase | Antitoxin |
| L1A04_RS10130 (2017937) | 2017937..2018089 | + | 153 | WP_000031108.1 | SAS053 family protein | Toxin |
| L1A04_RS10135 (2018690) | 2018690..2019085 | + | 396 | WP_000901019.1 | hypothetical protein | - |
| L1A04_RS10140 (2019281) | 2019281..2020666 | + | 1386 | WP_000116227.1 | class II fumarate hydratase | - |
| L1A04_RS10145 (2021122) | 2021122..2021943 | - | 822 | WP_000669380.1 | RluA family pseudouridine synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5936.28 Da Isoelectric Point: 3.8962
>T232037 WP_000031108.1 NZ_CP090879:2017937-2018089 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
Download Length: 153 bp
>T232037 NZ_CP127228:c1586134-1585550 [Pseudomonas tohonis]
ATGAACATCGACATCATCAGGGCGCGGCTCGACTTCCTGCGTGAGGCGGAGCGCCTCAAGGATGTGCTGCGCAGCGCCCA
CACCTCTTCCGGGCGGGCGGAAAGCACCGCCGAGCACAGCTGGCGCCTGTGCCTGATGGCCATCACCTTCGCCGACGAGC
TGGCCGGGCTCGACCTGCTGCGGGTGCTGAAGATGTGCGTGGTGCACGACCTGGGCGAGGCCATCCATGGCGACATCCCC
GCCGTCGAGCAGGGCGGCCACCCCGACAAGGGGGCCCAGGAGCGCGAGGACCTGCTGACCCTGACCCGCACCCTGGACGA
TGGGCTGCGCGGGGAGATCCTCGCGCTGTGGGACGACTACGAGAACGCCGCCTCCCCAGAGGCGCTGGCGGTCAAGGCGC
TGGACAAGCTGGAGACCCTGCTGCAGCACACCCAGGGCGCCAACCCGGAGGACTTCGACTACGCCTTCAACCTCGGCTAC
GGGCGCCGCTACACCAGCGGCGAACCGCTGTTCGCGGCCATCCGTGCACAGCTGGACGAGGACACGAGGCGGCGGATGGA
GGCGCAGGCAAGCGTACCTCGCTGA
ATGAACATCGACATCATCAGGGCGCGGCTCGACTTCCTGCGTGAGGCGGAGCGCCTCAAGGATGTGCTGCGCAGCGCCCA
CACCTCTTCCGGGCGGGCGGAAAGCACCGCCGAGCACAGCTGGCGCCTGTGCCTGATGGCCATCACCTTCGCCGACGAGC
TGGCCGGGCTCGACCTGCTGCGGGTGCTGAAGATGTGCGTGGTGCACGACCTGGGCGAGGCCATCCATGGCGACATCCCC
GCCGTCGAGCAGGGCGGCCACCCCGACAAGGGGGCCCAGGAGCGCGAGGACCTGCTGACCCTGACCCGCACCCTGGACGA
TGGGCTGCGCGGGGAGATCCTCGCGCTGTGGGACGACTACGAGAACGCCGCCTCCCCAGAGGCGCTGGCGGTCAAGGCGC
TGGACAAGCTGGAGACCCTGCTGCAGCACACCCAGGGCGCCAACCCGGAGGACTTCGACTACGCCTTCAACCTCGGCTAC
GGGCGCCGCTACACCAGCGGCGAACCGCTGTTCGCGGCCATCCGTGCACAGCTGGACGAGGACACGAGGCGGCGGATGGA
GGCGCAGGCAAGCGTACCTCGCTGA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22357.50 Da Isoelectric Point: 5.1445
>AT232037 WP_001251219.1 NZ_CP090879:2017313-2017912 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
Download Length: 600 bp
>AT232037 NZ_CP127228:c1586803-1586246 [Pseudomonas tohonis]
ATGCACGACAGCCTCCCGAAACCGGTCTCGCTCGGCCTCGCGCTGCGCCGTTGGCGCCTGTTGCACCGGGTGAAGCAGGC
CCACGCCGCGCAGCTGTTCGGCGTCGCCCAGTCGACCATCTCGCGCTGGGAAAGCGGGGCGCAGGCGATGGAGCCGGCCG
AGCGCGCGCGGGTGGAGCAGGTGCTTGGCGCCCGGCTGGAGGCGGCGGCCGACCAGGCCCTGGCGCGGCTGGTGGGCGAC
AGCCCGCGCGCGGTGCACCTGGTCTGCGACCTGAGCCATCGCCTGCTGGCCTGTTCCGCCCTGCGCGCCGCCGAATTCAG
CGTGCCCCTCTCCGAGCTGCTGGGCCGCTCGCTGTGGCGCTACGCGACGCCGGAGATCGTGCGCCAGGAGGACGCGCTGG
ACGCCCTGGGCTGGCGCGACGTGCTGATGCCGCCGGCGCTGGAGTTCGGCAGCGGCAGCAACGAGTCCGCCATCGTGCCG
ATCCGCCAGGGCCTGTGCCGCTGGACGCGCATGACGCTTTCCGACGGCACCGCTGCGCGCCTGGTGGAAACCCTCTGA
ATGCACGACAGCCTCCCGAAACCGGTCTCGCTCGGCCTCGCGCTGCGCCGTTGGCGCCTGTTGCACCGGGTGAAGCAGGC
CCACGCCGCGCAGCTGTTCGGCGTCGCCCAGTCGACCATCTCGCGCTGGGAAAGCGGGGCGCAGGCGATGGAGCCGGCCG
AGCGCGCGCGGGTGGAGCAGGTGCTTGGCGCCCGGCTGGAGGCGGCGGCCGACCAGGCCCTGGCGCGGCTGGTGGGCGAC
AGCCCGCGCGCGGTGCACCTGGTCTGCGACCTGAGCCATCGCCTGCTGGCCTGTTCCGCCCTGCGCGCCGCCGAATTCAG
CGTGCCCCTCTCCGAGCTGCTGGGCCGCTCGCTGTGGCGCTACGCGACGCCGGAGATCGTGCGCCAGGAGGACGCGCTGG
ACGCCCTGGGCTGGCGCGACGTGCTGATGCCGCCGGCGCTGGAGTTCGGCAGCGGCAGCAACGAGTCCGCCATCGTGCCG
ATCCGCCAGGGCCTGTGCCGCTGGACGCGCATGACGCTTTCCGACGGCACCGCTGCGCGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | X5E2E6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D1IYN8 |