Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1831642..1832171 Replicon chromosome
Accession NZ_CP090879
Organism Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag L1A04_RS09000 Protein ID WP_000621176.1
Coordinates 1831809..1832171 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag L1A04_RS08995 Protein ID WP_000948331.1
Coordinates 1831642..1831812 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A04_RS08965 (1826678) 1826678..1827238 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
L1A04_RS08970 (1827447) 1827447..1827926 + 480 WP_001287082.1 hypothetical protein -
L1A04_RS08975 (1827919) 1827919..1829496 + 1578 WP_001294646.1 PH domain-containing protein -
L1A04_RS08980 (1829489) 1829489..1829980 + 492 WP_001286801.1 PH domain-containing protein -
L1A04_RS08985 (1829984) 1829984..1830343 + 360 WP_234877937.1 holo-ACP synthase -
L1A04_RS08990 (1830409) 1830409..1831557 + 1149 WP_001281140.1 alanine racemase -
L1A04_RS08995 (1831642) 1831642..1831812 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
L1A04_RS09000 (1831809) 1831809..1832171 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L1A04_RS09005 (1832521) 1832521..1833522 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
L1A04_RS09010 (1833641) 1833641..1833967 + 327 WP_001052491.1 anti-sigma factor antagonist -
L1A04_RS09015 (1833969) 1833969..1834448 + 480 WP_001190825.1 anti-sigma B factor RsbW -
L1A04_RS09020 (1834423) 1834423..1835193 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T232033 WP_000621176.1 NZ_CP090879:1831809-1832171 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T232033 NZ_CP127225:c4484572-4484438 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT232033 WP_000948331.1 NZ_CP090879:1831642-1831812 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT232033 NZ_CP127225:c4484799-4484647 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References