Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1810921..1811435 Replicon chromosome
Accession NZ_CP090879
Organism Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag L1A04_RS08905 Protein ID WP_000581791.1
Coordinates 1811226..1811435 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag L1A04_RS08900 Protein ID WP_000138934.1
Coordinates 1810921..1811214 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A04_RS08875 (1806384) 1806384..1807025 + 642 WP_000483150.1 thiamine phosphate synthase -
L1A04_RS08880 (1807111) 1807111..1807983 + 873 WP_000725802.1 membrane protein insertase YidC -
L1A04_RS08885 (1808140) 1808140..1808439 - 300 WP_001793952.1 hypothetical protein -
L1A04_RS08890 (1808596) 1808596..1809243 - 648 WP_001187612.1 HD domain-containing protein -
L1A04_RS08895 (1809271) 1809271..1810755 - 1485 WP_033845100.1 cardiolipin synthase -
L1A04_RS08900 (1810921) 1810921..1811214 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
L1A04_RS08905 (1811226) 1811226..1811435 + 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
L1A04_RS08910 (1811563) 1811563..1811700 + 138 WP_000828354.1 Lmo0850 family protein -
L1A04_RS08915 (1812112) 1812112..1812795 + 684 Protein_1750 transposase -
L1A04_RS08920 (1812956) 1812956..1814158 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
L1A04_RS08925 (1814476) 1814476..1815546 + 1071 WP_000159638.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T232032 WP_000581791.1 NZ_CP090879:1811226-1811435 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T232032 NZ_CP127223:c1382715-1381969 [Bacillus licheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTTATTGTTTTGGCGCTGGCTCTGTACGTAGCTGCCGTGTGGCGTTTTGA
AAAACAGCTCGCCGAAAAAACGGTCGCCATCAGAAAAACGTGGTACCTTCTTTATGTCATCGGCGCCGTGATATATTGGA
CGCACGATCCGCAGTCAATTTTCACAAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGTTGACAGACGCTTTT
ATTTTCTTAAATGCCTACTTTAAAAAGCTCGGCAGCTCTGAACTCGCGACAGATACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACGTATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGCATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
CCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGATTATCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT232032 WP_000138934.1 NZ_CP090879:1810921-1811214 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT232032 NZ_CP127223:c1381969-1381796 [Bacillus licheniformis]
ATGGAGCCTGCTTTTCAGCAAGACCAGGAAAGCGTAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAGGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References