Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 326286..326763 Replicon chromosome
Accession NZ_CP090879
Organism Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag L1A04_RS01750 Protein ID WP_000052076.1
Coordinates 326575..326763 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag L1A04_RS01745 Protein ID WP_001059690.1
Coordinates 326286..326546 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A04_RS01710 (321678) 321678..322394 - 717 WP_000150022.1 type I 3-dehydroquinate dehydratase -
L1A04_RS01715 (322542) 322542..322964 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
L1A04_RS01720 (323363) 323363..323857 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
L1A04_RS01725 (324013) 324013..324630 + 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
L1A04_RS01730 (324703) 324703..325284 - 582 WP_001140696.1 histidine phosphatase family protein -
L1A04_RS01735 (325509) 325509..325745 + 237 WP_000368687.1 hypothetical protein -
L1A04_RS01740 (325742) 325742..325945 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
L1A04_RS01745 (326286) 326286..326546 + 261 WP_001059690.1 hypothetical protein Antitoxin
L1A04_RS01750 (326575) 326575..326763 + 189 WP_000052076.1 hypothetical protein Toxin
L1A04_RS01755 (326951) 326951..327520 + 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
L1A04_RS01760 (327608) 327608..327892 + 285 WP_001004401.1 hypothetical protein -
L1A04_RS01765 (327954) 327954..328172 + 219 WP_000005879.1 hypothetical protein -
L1A04_RS01770 (328669) 328669..328869 - 201 WP_001059082.1 cold-shock protein -
L1A04_RS01775 (329226) 329226..329912 - 687 WP_001574556.1 thermonuclease family protein -
L1A04_RS01780 (330253) 330253..330810 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T232023 WP_000052076.1 NZ_CP090879:326575-326763 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T232023 NZ_CP127177:492407-492523 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT232023 WP_001059690.1 NZ_CP090879:326286-326546 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT232023 NZ_CP127177:c492639-492434 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References