232013

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2037381..2037895 Replicon chromosome
Accession NZ_CP090877
Organism Staphylococcus aureus strain SAUR_BFS11

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag L1A06_RS09970 Protein ID WP_000581792.1
Coordinates 2037686..2037895 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag L1A06_RS09965 Protein ID WP_000138932.1
Coordinates 2037381..2037674 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A06_RS09945 (2032730) 2032730..2033371 + 642 WP_000483153.1 thiamine phosphate synthase -
L1A06_RS09950 (2033457) 2033457..2034329 + 873 WP_000725802.1 membrane protein insertase YidC -
L1A06_RS09955 (2035056) 2035056..2035703 - 648 WP_001187634.1 HD domain-containing protein -
L1A06_RS09960 (2035731) 2035731..2037215 - 1485 WP_000571549.1 cardiolipin synthase -
L1A06_RS09965 (2037381) 2037381..2037674 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
L1A06_RS09970 (2037686) 2037686..2037895 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
L1A06_RS09975 (2038023) 2038023..2038160 + 138 WP_000828354.1 Lmo0850 family protein -
L1A06_RS09980 (2038424) 2038424..2039626 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
L1A06_RS09985 (2039944) 2039944..2041014 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
L1A06_RS09990 (2041029) 2041029..2042387 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T232013 WP_000581792.1 NZ_CP090877:2037686-2037895 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T232013 NZ_CP127158:869-1135 [Klebsiella pneumoniae subsp. pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT232013 WP_000138932.1 NZ_CP090877:2037381-2037674 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT232013 NZ_CP127158:661-885 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References