Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 580253..580730 Replicon chromosome
Accession NZ_CP090877
Organism Staphylococcus aureus strain SAUR_BFS11

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag L1A06_RS02930 Protein ID WP_000052076.1
Coordinates 580542..580730 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag L1A06_RS02925 Protein ID WP_001059690.1
Coordinates 580253..580513 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A06_RS02895 (575412) 575412..575906 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
L1A06_RS02900 (576246) 576246..577892 + 1647 WP_000277718.1 IS1182 family transposase -
L1A06_RS02905 (577980) 577980..578597 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
L1A06_RS02910 (578670) 578670..579251 - 582 WP_001140693.1 histidine phosphatase family protein -
L1A06_RS02915 (579476) 579476..579712 + 237 WP_000368687.1 hypothetical protein -
L1A06_RS02920 (579709) 579709..579912 - 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
L1A06_RS02925 (580253) 580253..580513 + 261 WP_001059690.1 hypothetical protein Antitoxin
L1A06_RS02930 (580542) 580542..580730 + 189 WP_000052076.1 hypothetical protein Toxin
L1A06_RS02935 (580918) 580918..581487 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
L1A06_RS02940 (581575) 581575..581859 + 285 WP_001004401.1 hypothetical protein -
L1A06_RS02945 (581921) 581921..582139 + 219 WP_000005886.1 hypothetical protein -
L1A06_RS02950 (582635) 582635..582835 - 201 WP_001059082.1 cold-shock protein -
L1A06_RS02955 (583192) 583192..583878 - 687 WP_001641381.1 thermonuclease family protein -
L1A06_RS02960 (584219) 584219..584689 - 471 WP_000824467.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 576246..577892 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T232004 WP_000052076.1 NZ_CP090877:580542-580730 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T232004 NZ_CP127153:c4941630-4941346 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT232004 WP_001059690.1 NZ_CP090877:580253-580513 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT232004 NZ_CP127153:c4941862-4941620 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References