Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 523920..524538 Replicon chromosome
Accession NC_011415
Organism Escherichia coli SE11

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ECSE_RS02490 Protein ID WP_001291435.1
Coordinates 523920..524138 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag ECSE_RS02495 Protein ID WP_000344794.1
Coordinates 524164..524538 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSE_RS02460 519210..519782 + 573 WP_000779831.1 YbaY family lipoprotein -
ECSE_RS02465 519813..520124 - 312 WP_000409911.1 MGMT family protein -
ECSE_RS02470 520503..520856 + 354 WP_000878140.1 DUF1428 domain-containing protein -
ECSE_RS02475 520898..522448 - 1551 WP_024210444.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ECSE_RS02480 522612..523082 - 471 WP_000136192.1 YlaC family protein -
ECSE_RS02485 523198..523749 - 552 WP_000102564.1 maltose O-acetyltransferase -
ECSE_RS02490 523920..524138 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
ECSE_RS02495 524164..524538 - 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
ECSE_RS02500 525084..528233 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
ECSE_RS02505 528256..529449 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T23200 WP_001291435.1 NC_011415:c524138-523920 [Escherichia coli SE11]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T23200 NC_011415:c524138-523920 [Escherichia coli SE11]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT23200 WP_000344794.1 NC_011415:c524538-524164 [Escherichia coli SE11]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT23200 NC_011415:c524538-524164 [Escherichia coli SE11]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCCGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References