Detailed information of TA system TA231991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 357216..357989
• Replicon: chromosome
• Accession: NZ_CP090876
• Organism: Staphylococcus aureus strain SAUR_BFS12

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: L0998_RS01990
• Protein ID: WP_054189550.1
• Coordinates: 357840..357989 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0D1IYN8
• Locus tag: L0998_RS01985
• Protein ID: WP_001251219.1
• Coordinates: 357216..357815 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0998_RS01965 (353132)	353132..354589	+	1458	WP_054189548.1	ABC transporter permease subunit	-
L0998_RS01970 (354582)	354582..355304	+	723	WP_054189583.1	amino acid ABC transporter ATP-binding protein	-
L0998_RS01975 (355455)	355455..356582	+	1128	WP_054189549.1	tRNA epoxyqueuosine(34) reductase QueG	-
L0998_RS01980 (356587)	356587..357057	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
L0998_RS01985 (357216)	357216..357815	+	600	WP_001251219.1	glucosamine-6-phosphate isomerase	Antitoxin
L0998_RS01990 (357840)	357840..357989	+	150	WP_054189550.1	SAS053 family protein	Toxin
L0998_RS01995 (358654)	358654..359049	+	396	WP_000901023.1	hypothetical protein	-
L0998_RS02000 (359245)	359245..360630	+	1386	WP_054189551.1	class II fumarate hydratase	-
L0998_RS02005 (361097)	361097..361918	-	822	WP_054189552.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5862.20 Da
• Isoelectric Point: 3.9075

>T231991 WP_054189550.1 NZ_CP090876:357840-357989 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVNDFEDLKELGKEMEQISDQNEQEKNSEEDN

Nucleotide

• Length: 150 bp

>T231991 NZ_CP127126:278723-279049 [Pseudomonas aeruginosa PA14]
ATGAATGACCCCGTGTACTGCCCGGTTCTTGGGTATGACGCGGTGTTGCTTGTCAACATCTCGACTGTCTATCCAGATAA
GTATTTCGATCAGTCATGCATTCTAAAGAAGGGTTGTCATCCCTTTGTTCTGCGCGACAGCTGGGTCGTATACCGCGAGG
CAGGCCCTTTCAACCTTGCACGGCTTGAGCAAGGGGTAGCGCAGAAGTCCATCAAGACGCATCAGCCCATCAACGCAGGC
GATTTCACTCGGATTCGGGCAGGCTTCGACATCTCGCCCGACGTCAAAATCAAAGTTGAGCGGTTCATGAGGCAGCACAA
GATTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22357.50 Da
• Isoelectric Point: 5.1445

>AT231991 WP_001251219.1 NZ_CP090876:357216-357815 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT231991 NZ_CP127126:278094-278651 [Pseudomonas aeruginosa PA14]
GTGATCTTCAGTGAACAGAAAGTGGCTCACATGGCAGCTTTCTTTTTGGCGAGTGCCGAAGGGCCGCTGCCTCATCTCAC
GCTGATCAAACTGCTGTACCTGGCAGACCGAGAGTCGATGGCTCGTTTCGACGTTCCCATGTCGGACGATCGAGCTGTTT
CCATGCCCCATGGGCCTGTCCTTTCCTCGACGCTAGACCTCATCAAGGGGCGTTTGCGCTCTGAGGTTTGGAGCGCTTGG
ATTTCTCCGTTGGTGGATCACGAGGTCCGTCTGGTCCATGACGTGGAGAATTGGGACGATCTGGATGAGTTGAGCCGATC
GGATCGCAGCATTTTGGAATCGGTCTGGCAAGAGTTTGGCCACATGACCAAGTACCAATTGCGGGACTACACCCACCATC
ACATTGGTGAGTGGCACGACCCCCACGGCTCTTCCAGGGACATTGATCCAAAGGATACTTTCATGGCGCTTGGTCAAAGC
GAGGAGCTGGCGGAGATCAAGGCGCGCGATCTTGCTGAGCGCCGTCGGCACGGTAGGAAGCTGTCTGAGTTCATTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0D1IYN8