23199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 489625..490462 Replicon chromosome
Accession NC_011415
Organism Escherichia coli SE11

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag ECSE_RS02320 Protein ID WP_000227784.1
Coordinates 489625..490167 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag ECSE_RS02325 Protein ID WP_001297137.1
Coordinates 490151..490462 (-) Length 104 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSE_RS02300 485164..486075 - 912 WP_000705874.1 2-dehydropantoate 2-reductase -
ECSE_RS02305 486243..486734 + 492 WP_001138904.1 nucleotide binding protein YajQ -
ECSE_RS02310 486862..488226 - 1365 WP_001000978.1 MFS transporter -
ECSE_RS02315 488634..489569 + 936 WP_001297127.1 sel1 repeat family protein -
ECSE_RS02320 489625..490167 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
ECSE_RS02325 490151..490462 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
ECSE_RS02330 490647..491537 - 891 WP_000971336.1 heme o synthase -
ECSE_RS02335 491549..491878 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
ECSE_RS02340 491878..492492 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
ECSE_RS02345 492482..494473 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
ECSE_RS02350 494495..495442 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(68-156)

Antitoxin

(14-97)


Sequences


Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T23199 WP_000227784.1 NC_011415:c490167-489625 [Escherichia coli SE11]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T23199 NC_011415:c490167-489625 [Escherichia coli SE11]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT23199 WP_001297137.1 NC_011415:c490462-490151 [Escherichia coli SE11]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT23199 NC_011415:c490462-490151 [Escherichia coli SE11]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
TGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BYY


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References