Detailed information of TA system TA231989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 139988..140502
• Replicon: chromosome
• Accession: NZ_CP090876
• Organism: Staphylococcus aureus strain SAUR_BFS12

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: L0998_RS00660
• Protein ID: WP_054190442.1
• Coordinates: 140293..140502 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: L0998_RS00655
• Protein ID: WP_000138934.1
• Coordinates: 139988..140281 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0998_RS00635 (135480)	135480..136121	+	642	WP_054190444.1	thiamine phosphate synthase	-
L0998_RS00640 (136207)	136207..137079	+	873	WP_000725800.1	membrane protein insertase YidC	-
L0998_RS00645 (137659)	137659..138306	-	648	WP_001187616.1	HD domain-containing protein	-
L0998_RS00650 (138334)	138334..139818	-	1485	WP_054190443.1	cardiolipin synthase	-
L0998_RS00655 (139988)	139988..140281	+	294	WP_000138934.1	copper-sensing transcriptional repressor CsoR	Antitoxin
L0998_RS00660 (140293)	140293..140502	+	210	WP_054190442.1	heavy metal-associated domain-containing protein	Toxin
L0998_RS00665 (140630)	140630..140767	+	138	WP_000828354.1	Lmo0850 family protein	-
L0998_RS00670 (141031)	141031..142233	-	1203	WP_054190441.1	FtsW/RodA/SpoVE family cell cycle protein	-
L0998_RS00675 (142551)	142551..143621	+	1071	WP_054190440.1	D-alanine--D-alanine ligase	-
L0998_RS00680 (143636)	143636..144994	+	1359	WP_054190439.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7830.77 Da
• Isoelectric Point: 4.1008

>T231989 WP_054190442.1 NZ_CP090876:140293-140502 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISSMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKILF

Nucleotide

• Length: 210 bp

>T231989 NZ_CP127115:1626310-1626600 [Paenarthrobacter sp. R1]
GTGAGCAATTCCAGCTTGGAGGGCGAGCCGTGGAACATTCAGGTCACAAGTCCGGCACTGAAAACATTTCATCGGCTTCC
CGAAAAGGCCGCCTCCGCCATAGTGGAGTTCATAACCGGGGCCCTGGCAGGCAACCCACACCGCCTCAGCAAACCCCTGA
CCAATGAACTTCTTGGCATGCGCACCGCCCGCCGAGGTGATTACCGCGTGTTGTTCACCCTCGACATCGAGGACCACGTG
CTCTATGTCCATCGAATTCAGCACCGCGCAGATGTCTACAAACCTCGCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT231989 WP_000138934.1 NZ_CP090876:139988-140281 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT231989 NZ_CP127115:1626038-1626313 [Paenarthrobacter sp. R1]
ATGAAGACGGTTCCCCTCAGCGAGGCCAAGGACAAACTCTCGGCCTTGGTCGAAGAAGCAGACACCACACACGAAATCAT
TCAGATCACTCGCCACGGACACCCGTCGGCCGTCCTCATGTCTGCGGATGACCTGGAATCACTTCAGGAAACCATCCACT
GGCTGTCCCAACCGGGCCTACGTGAGGATCTTGCACAGGCTCGCCGCGATATCGCAGAGGGCAACACAGTAAGCGGCGAT
GACCTGCGCCGTGAATTCGGACTGCCTCCCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0D1GBN9