Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2724585..2725062 | Replicon | chromosome |
| Accession | NZ_CP090873 | ||
| Organism | Staphylococcus aureus strain SAUR_BFS16 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | L1A02_RS13505 | Protein ID | WP_000052076.1 |
| Coordinates | 2724874..2725062 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | L1A02_RS13500 | Protein ID | WP_001059690.1 |
| Coordinates | 2724585..2724845 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A02_RS13465 (2719978) | 2719978..2720694 | - | 717 | WP_234863249.1 | type I 3-dehydroquinate dehydratase | - |
| L1A02_RS13470 (2720842) | 2720842..2721264 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| L1A02_RS13475 (2721663) | 2721663..2722157 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| L1A02_RS13480 (2722312) | 2722312..2722929 | + | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
| L1A02_RS13485 (2723002) | 2723002..2723583 | - | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| L1A02_RS13490 (2723808) | 2723808..2724044 | + | 237 | WP_000349581.1 | hypothetical protein | - |
| L1A02_RS13495 (2724041) | 2724041..2724244 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| L1A02_RS13500 (2724585) | 2724585..2724845 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| L1A02_RS13505 (2724874) | 2724874..2725062 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| L1A02_RS13510 (2725250) | 2725250..2725819 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| L1A02_RS13515 (2725907) | 2725907..2726191 | + | 285 | WP_001004399.1 | hypothetical protein | - |
| L1A02_RS13520 (2726253) | 2726253..2726471 | + | 219 | WP_000005886.1 | hypothetical protein | - |
| L1A02_RS13525 (2726963) | 2726963..2727163 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| L1A02_RS13530 (2727520) | 2727520..2728206 | - | 687 | WP_000141557.1 | thermonuclease family protein | - |
| L1A02_RS13535 (2728547) | 2728547..2729068 | - | 522 | WP_234863250.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 2721663..2782078 | 60415 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T231988 WP_000052076.1 NZ_CP090873:2724874-2725062 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T231988 NZ_CP127114:c3503737-3503351 [Pseudomonas sp. M2(2023)]
TTGCGTGTCAGCGGCCGCTGGCACCAGGCGGGCCGGCCAGTGGTGTATGCCGCCACCAGCCCGGCCGGGGCGATGCTGGA
GGTGCTGGTGCACCTGGAGATCGACCCTGAGGATTTCCCCACCACCATGCGGCTGCTGCGTATCGAGTTGCCTGACACCG
TTTCGCAAGCGCAGTTGCCCGCCTTGCAGCCTGGCTGGTCGAGCCAGACCGAACTGACCCGGGGCCTGGGCAACCGCTTT
CTGGATGAGTGTTCGGCGTTGCTGCTGCCGGTGCCGAGCGCGATCATGCCCAGCACCACCAATTACCTTTTCAACCCGCG
CCATCCGCAGGCAAACAGTGCCAGGCTCGAGGTCGAGGACTTCACCCCGGACAGCCGGCTGTTTTAG
TTGCGTGTCAGCGGCCGCTGGCACCAGGCGGGCCGGCCAGTGGTGTATGCCGCCACCAGCCCGGCCGGGGCGATGCTGGA
GGTGCTGGTGCACCTGGAGATCGACCCTGAGGATTTCCCCACCACCATGCGGCTGCTGCGTATCGAGTTGCCTGACACCG
TTTCGCAAGCGCAGTTGCCCGCCTTGCAGCCTGGCTGGTCGAGCCAGACCGAACTGACCCGGGGCCTGGGCAACCGCTTT
CTGGATGAGTGTTCGGCGTTGCTGCTGCCGGTGCCGAGCGCGATCATGCCCAGCACCACCAATTACCTTTTCAACCCGCG
CCATCCGCAGGCAAACAGTGCCAGGCTCGAGGTCGAGGACTTCACCCCGGACAGCCGGCTGTTTTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT231988 WP_001059690.1 NZ_CP090873:2724585-2724845 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT231988 NZ_CP127114:c3504234-3503785 [Pseudomonas sp. M2(2023)]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCCTGCATGCACTGCTGGAAATCCCCGAACT
CGCCAGTGACTTCGAAATCCACACCCGCATCACCCATGGCTTCGCTGCCACCTGGCTGGTGAAACTGACCGAACTCGGCG
TGTTCACCCCTGTGGAGCGTGACCAGATCATTCCCCTGCGCACGCTGAAAACCCGCATCGAACGTGACCAGCCGCTGACC
GTGGAAGAAAGCGACCGGCTGTTCCGTTCGGCCCATATCACCGCCATGGCCGAAGCCGTGTTCGGCGAGGCAGGCAAGGC
AAAACGCTGGCTGTCCAAGCCCAAGGAGCGCTTCTCGGGGCTGACGCCGATGCAGATGCTAACCACCCAGCAGGGCACCA
CCCAGGTCGAAGAGATGTTGCTGCAGATCGCCGAGGGCTTCGGCCTGTGA
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCCTGCATGCACTGCTGGAAATCCCCGAACT
CGCCAGTGACTTCGAAATCCACACCCGCATCACCCATGGCTTCGCTGCCACCTGGCTGGTGAAACTGACCGAACTCGGCG
TGTTCACCCCTGTGGAGCGTGACCAGATCATTCCCCTGCGCACGCTGAAAACCCGCATCGAACGTGACCAGCCGCTGACC
GTGGAAGAAAGCGACCGGCTGTTCCGTTCGGCCCATATCACCGCCATGGCCGAAGCCGTGTTCGGCGAGGCAGGCAAGGC
AAAACGCTGGCTGTCCAAGCCCAAGGAGCGCTTCTCGGGGCTGACGCCGATGCAGATGCTAACCACCCAGCAGGGCACCA
CCCAGGTCGAAGAGATGTTGCTGCAGATCGCCGAGGGCTTCGGCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |