Detailed information of TA system TA231985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1690214..1690990
• Replicon: chromosome
• Accession: NZ_CP090873
• Organism: Staphylococcus aureus strain SAUR_BFS16

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: L1A02_RS08535
• Protein ID: WP_000031108.1
• Coordinates: 1690838..1690990 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: L1A02_RS08530
• Protein ID: WP_001251224.1
• Coordinates: 1690214..1690813 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A02_RS08510 (1686130)	1686130..1687587	+	1458	WP_000649908.1	ABC transporter permease subunit	-
L1A02_RS08515 (1687580)	1687580..1688302	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
L1A02_RS08520 (1688453)	1688453..1689580	+	1128	WP_234863234.1	tRNA epoxyqueuosine(34) reductase QueG	-
L1A02_RS08525 (1689585)	1689585..1690055	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
L1A02_RS08530 (1690214)	1690214..1690813	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
L1A02_RS08535 (1690838)	1690838..1690990	+	153	WP_000031108.1	SAS053 family protein	Toxin
L1A02_RS08540 (1691538)	1691538..1691933	+	396	WP_000901023.1	hypothetical protein	-
L1A02_RS08545 (1692129)	1692129..1693514	+	1386	WP_016170518.1	class II fumarate hydratase	-
L1A02_RS08550 (1693967)	1693967..1694788	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T231985 WP_000031108.1 NZ_CP090873:1690838-1690990 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T231985 NZ_CP127101:827544-827897 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT231985 WP_001251224.1 NZ_CP090873:1690214-1690813 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT231985 NZ_CP127101:827373-827543 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4