Detailed information of TA system TA231980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1530276..1530793
• Replicon: chromosome
• Accession: NZ_CP090873
• Organism: Staphylococcus aureus strain SAUR_BFS16

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: L1A02_RS07430
• Protein ID: WP_000383748.1
• Coordinates: 1530488..1530793 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: L1A02_RS07425
• Protein ID: WP_001058491.1
• Coordinates: 1530276..1530485 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A02_RS07390 (1525522)	1525522..1525806	+	285	WP_000917289.1	co-chaperone GroES	-
L1A02_RS07395 (1525882)	1525882..1527498	+	1617	WP_000240642.1	chaperonin GroEL	-
L1A02_RS07400 (1527567)	1527567..1528739	-	1173	WP_000179346.1	tyrosine-type recombinase/integrase	-
L1A02_RS07405 (1528753)	1528753..1529427	-	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
L1A02_RS07410 (1529600)	1529600..1529818	+	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
L1A02_RS07415 (1529823)	1529823..1530140	+	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
L1A02_RS07420 (1530137)	1530137..1530283	+	147	WP_076742779.1	pathogenicity island protein	-
L1A02_RS07425 (1530276)	1530276..1530485	+	210	WP_001058491.1	hypothetical protein	Antitoxin
L1A02_RS07430 (1530488)	1530488..1530793	+	306	WP_000383748.1	DUF1474 family protein	Toxin
L1A02_RS07435 (1530868)	1530868..1532484	+	1617	WP_076747260.1	phage resistance protein	-
L1A02_RS07440 (1532660)	1532660..1533463	+	804	WP_000148373.1	bifunctional DNA primase/polymerase	-
L1A02_RS07445 (1533450)	1533450..1533722	+	273	WP_234863228.1	pathogenicity island protein	-
L1A02_RS07450 (1533724)	1533724..1534365	+	642	WP_234863229.1	pathogenicity island protein	-
L1A02_RS07455 (1535075)	1535075..1535419	+	345	WP_001288441.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / seb / hlb / sak / chp / scn	1525522..1592505	66983

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12111.32 Da
• Isoelectric Point: 4.1625

>T231980 WP_000383748.1 NZ_CP090873:1530488-1530793 [Staphylococcus aureus]
MDWEIKSLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDA

Nucleotide

• Length: 306 bp

>T231980 NZ_CP090873:1530488-1530793 [Staphylococcus aureus]
ATGGATTGGGAAATTAAAAGTTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.32 Da
• Isoelectric Point: 4.5099

>AT231980 WP_001058491.1 NZ_CP090873:1530276-1530485 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAEKLKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT231980 NZ_CP090873:1530276-1530485 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCAGAAAAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA