Detailed information of TA system TA231979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1478083..1478612
• Replicon: chromosome
• Accession: NZ_CP090873
• Organism: Staphylococcus aureus strain SAUR_BFS16

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: L1A02_RS07160
• Protein ID: WP_000621175.1
• Coordinates: 1478250..1478612 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: L1A02_RS07155
• Protein ID: WP_000948331.1
• Coordinates: 1478083..1478253 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A02_RS07125 (1473120)	1473120..1473680	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
L1A02_RS07130 (1473888)	1473888..1474367	+	480	WP_001287087.1	hypothetical protein	-
L1A02_RS07135 (1474360)	1474360..1475943	+	1584	WP_001294626.1	PH domain-containing protein	-
L1A02_RS07140 (1475930)	1475930..1476421	+	492	WP_001205912.1	PH domain-containing protein	-
L1A02_RS07145 (1476425)	1476425..1476784	+	360	WP_000581197.1	holo-ACP synthase	-
L1A02_RS07150 (1476850)	1476850..1477998	+	1149	WP_234863226.1	alanine racemase	-
L1A02_RS07155 (1478083)	1478083..1478253	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
L1A02_RS07160 (1478250)	1478250..1478612	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
L1A02_RS07165 (1478962)	1478962..1479963	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
L1A02_RS07170 (1480082)	1480082..1480408	+	327	WP_001052491.1	anti-sigma factor antagonist	-
L1A02_RS07175 (1480410)	1480410..1480889	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
L1A02_RS07180 (1480864)	1480864..1481634	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T231979 WP_000621175.1 NZ_CP090873:1478250-1478612 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T231979 NZ_CP127099:286559-286840 [Trueperella bernardiae]
GTGATCATTTCTTTCGCTGACCGGGATACCGAGGCGCTCTACCTGCGACAGCCGGTAAGGTGGCTCGATTTCCGGTTGAA
CCGGCAAGCGCTGCAAAAACTGCGCTTACTCGATTCGGTGGTGGATCTCAACGAATTGAAGATTCCGCCCGGAAATCGGC
TCGAGGCCCTCAAGGGGGACCGGGCTGGCCAGTTCAGCATAAGAATCAACAATCAGTGGCAAATCTGCTTCGTTTGGACT
TTCATGGGTCCGAGTGAACTGGCGATCGTCGATTATCACTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT231979 WP_000948331.1 NZ_CP090873:1478083-1478253 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT231979 NZ_CP127099:286853-287152 [Trueperella bernardiae]
ATGGGGAAGAAGATTTCGCCGATCTCGCCCGGTGAAGTCCTCTTGGAAGAGTTCATTGGGCCGATGGGGATCACACAGAA
CAAGCTAGCCGTGGAGATCGGGGTTCCTCCGCGCCGGATCAACGAGATTGTTCACGGCAAGCGGCGCATTACTGCCGATA
CGGCCTTGCGCCTGGGACGGTATTTCGGAATGAGTGCACAGTTCTGGATCAATCTGCAGTCGCATTACGATTTGGAGATC
GAGATGGATGCGCTCGCGGACGAGTTGGATAAGATCACGCCCATCACCCGCGGGACATAG

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1