Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1084428..1084951 Replicon chromosome
Accession NZ_CP090873
Organism Staphylococcus aureus strain SAUR_BFS16

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag L1A02_RS05125 Protein ID WP_000074049.1
Coordinates 1084685..1084951 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag L1A02_RS05120 Protein ID WP_000587616.1
Coordinates 1084428..1084685 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A02_RS05105 (1080925) 1080925..1081674 - 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -
L1A02_RS05110 (1081869) 1081869..1083446 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
L1A02_RS05115 (1083614) 1083614..1084069 - 456 WP_000732076.1 DUF1307 domain-containing protein -
L1A02_RS05120 (1084428) 1084428..1084685 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1A02_RS05125 (1084685) 1084685..1084951 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
L1A02_RS05130 (1085306) 1085306..1086382 + 1077 WP_001076673.1 M42 family metallopeptidase -
L1A02_RS05135 (1086630) 1086630..1087292 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
L1A02_RS05140 (1087285) 1087285..1088061 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
L1A02_RS05145 (1088457) 1088457..1089644 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T231972 WP_000074049.1 NZ_CP090873:1084685-1084951 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T231972 NZ_CP127094:942396-942749 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT231972 WP_000587616.1 NZ_CP090873:1084428-1084685 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT231972 NZ_CP127094:942225-942395 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References