Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 583859..584373 Replicon chromosome
Accession NZ_CP090870
Organism Staphylococcus aureus strain SAUR_BFS62

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag L0999_RS03240 Protein ID WP_000581792.1
Coordinates 583859..584068 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag L0999_RS03245 Protein ID WP_000138932.1
Coordinates 584080..584373 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0999_RS03220 (579367) 579367..580725 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
L0999_RS03225 (580740) 580740..581810 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
L0999_RS03230 (582128) 582128..583330 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
L0999_RS03235 (583594) 583594..583731 - 138 WP_000828354.1 Lmo0850 family protein -
L0999_RS03240 (583859) 583859..584068 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
L0999_RS03245 (584080) 584080..584373 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
L0999_RS03250 (584539) 584539..586023 + 1485 WP_000571549.1 cardiolipin synthase -
L0999_RS03255 (586051) 586051..586698 + 648 WP_001187630.1 HD domain-containing protein -
L0999_RS03260 (587611) 587611..588483 - 873 WP_000725802.1 membrane protein insertase YidC -
L0999_RS03265 (588569) 588569..589210 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T231966 WP_000581792.1 NZ_CP090870:c584068-583859 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T231966 NZ_CP127045:4054471-4054755 [Pseudomonas amygdali pv. lachrymans]
ATGCAGGTTGAGTGGCTTAAAACGGCGCTAAAGAATCTGGATGAGGAGGCAGCGTATATCGCACAGGACAATCCAGCTGC
TGCCGCAGCTTTCGTGAAAGCAATTCAATCAAGCGTGACGCAGCTCGCGAGCTTTCCCGCCATGGGCCGGGAAGGACGGA
TTGCCGGAACCAGAGAATGGCCTCTGCCAGACCTGCCTTACCTGATTCCATATCGCATCCGTAGCGGCCGGCTACAGGTT
CTAAGGATTTTCCACACCAGAAGACAATCGCCCCCCGTGTGGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT231966 WP_000138932.1 NZ_CP090870:c584373-584080 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT231966 NZ_CP127045:4054242-4054481 [Pseudomonas amygdali pv. lachrymans]
ATGTCCACAATGTCTCTACGTCTGCCGGACGAAATGGCGGATACCCTTGCACACCTTGCAAAGGCGACCGGGCGCAGCAA
GTCATTTTTGGCCCTCGACGCGCTCCGCGAATACCTGACTCGCGAGGCATGGCAGATTGCCGAAATTCAGCGCGCGATTG
AAGAAGCCGACGCTGGCGAGTTCGCCAATACAGAGGACGTAAAAGCTGTCATGGACAAATGGTCTGGCAATGCAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References