Detailed information of TA system TA231964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 511939..512456
• Replicon: chromosome
• Accession: NZ_CP090870
• Organism: Staphylococcus aureus strain SAUR_BFS62

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: L0999_RS02880
• Protein ID: WP_000383748.1
• Coordinates: 511939..512244 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: L0999_RS02885
• Protein ID: WP_001058491.1
• Coordinates: 512247..512456 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0999_RS02855 (507313)	507313..507657	-	345	WP_001288441.1	hypothetical protein	-
L0999_RS02860 (508367)	508367..509008	-	642	WP_234863229.1	pathogenicity island protein	-
L0999_RS02865 (509010)	509010..509282	-	273	WP_234863228.1	pathogenicity island protein	-
L0999_RS02870 (509269)	509269..510072	-	804	WP_000148373.1	bifunctional DNA primase/polymerase	-
L0999_RS02875 (510248)	510248..511864	-	1617	WP_076747260.1	phage resistance protein	-
L0999_RS02880 (511939)	511939..512244	-	306	WP_000383748.1	DUF1474 family protein	Toxin
L0999_RS02885 (512247)	512247..512456	-	210	WP_001058491.1	hypothetical protein	Antitoxin
L0999_RS02890 (512449)	512449..512595	-	147	WP_076742779.1	pathogenicity island protein	-
L0999_RS02895 (512592)	512592..512909	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
L0999_RS02900 (512914)	512914..513132	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
L0999_RS02905 (513305)	513305..513979	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
L0999_RS02910 (513993)	513993..515165	+	1173	WP_000179346.1	tyrosine-type recombinase/integrase	-
L0999_RS02915 (515234)	515234..516850	-	1617	WP_000240642.1	chaperonin GroEL	-
L0999_RS02920 (516926)	516926..517210	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / seb / groEL	450227..517210	66983

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12111.32 Da
• Isoelectric Point: 4.1625

>T231964 WP_000383748.1 NZ_CP090870:c512244-511939 [Staphylococcus aureus]
MDWEIKSLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDA

Nucleotide

• Length: 306 bp

>T231964 NZ_CP127045:c624311-624021 [Pseudomonas amygdali pv. lachrymans]
ATGAACAACGAGACGACACCGTTCGATACCGTCGACTATTTGAAGACACCTGAAGATATGGCCAATTATCTGGATGCGTG
TCTTGAAGAGGATTCAGGAGACGGGCTGCTCGTAAGGGCCGCGCTGAACGACATAGCAAGGGCTTATGGCATGACACAAA
TCGCACGTGATACAGGTCTTGGTCGTGAGAGCCTCTACAAAGCGCTGGGTGCAAACGGTAATCCAGAGTTCACGACCATC
ATGAAAGTCGTGAGGGCGATGGGGATCAAACTACACGCAAGTACGCGCTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.32 Da
• Isoelectric Point: 4.5099

>AT231964 WP_001058491.1 NZ_CP090870:c512456-512247 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAEKLKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT231964 NZ_CP127045:c624616-624314 [Pseudomonas amygdali pv. lachrymans]
ATGAATCGCTTTGAACAGACGCCCGCTTTTGCGGAGTGGTTAAGGTCGTTGAAGGACTCCATTGGCAGAGCTCGAATTCT
GGCTCGAATAAGAGCAGCAGAGCTCGGTAACTTCGGGGACTGCGATGCTTTAGGTCAAGGCGTCAGAGAGCTACGAATAC
ACCATGGACCAGGTTATCGGGTGTATTTTGCCCGACGCACGGGTGTGGTTTACCTGCTCTTGATCGCTGGTGACAAATCG
TCTCAAAAGCGCGACATAAAATTTGCCAGACAGCTGGCGAGAGAGCTCTGTGAGAGGGAGTAA