Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3496773..3497410 Replicon chromosome
Accession NZ_CP090838
Organism Bacillus amyloliquefaciens strain TL106

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag LT978_RS17410 Protein ID WP_003156187.1
Coordinates 3496773..3497123 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag LT978_RS17415 Protein ID WP_003156188.1
Coordinates 3497129..3497410 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT978_RS17370 (LT978_17365) 3491813..3492415 - 603 WP_003156170.1 PP2C family serine/threonine-protein phosphatase -
LT978_RS17375 (LT978_17370) 3492415..3493203 - 789 WP_003156171.1 RNA polymerase sigma factor SigB -
LT978_RS17380 (LT978_17375) 3493169..3493651 - 483 WP_003156173.1 anti-sigma B factor RsbW -
LT978_RS17385 (LT978_17380) 3493648..3493977 - 330 WP_003156176.1 anti-sigma factor antagonist RsbV -
LT978_RS17390 (LT978_17385) 3494041..3495048 - 1008 WP_003156177.1 PP2C family protein-serine/threonine phosphatase -
LT978_RS17395 (LT978_17390) 3495060..3495461 - 402 WP_003156178.1 anti-sigma regulatory factor -
LT978_RS17400 (LT978_17395) 3495464..3495829 - 366 WP_003156180.1 RsbT antagonist protein RsbS -
LT978_RS17405 (LT978_17400) 3495834..3496655 - 822 WP_003156182.1 STAS domain-containing protein -
LT978_RS17410 (LT978_17405) 3496773..3497123 - 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LT978_RS17415 (LT978_17410) 3497129..3497410 - 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
LT978_RS17420 (LT978_17415) 3497530..3498699 - 1170 WP_003156189.1 alanine racemase -
LT978_RS17425 (LT978_17420) 3498816..3499823 - 1008 WP_003156191.1 outer membrane lipoprotein carrier protein LolA -
LT978_RS17430 (LT978_17425) 3499988..3500353 - 366 WP_014304402.1 holo-ACP synthase -
LT978_RS17435 (LT978_17430) 3500446..3501045 + 600 WP_003156193.1 rhomboid family intramembrane serine protease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin

(12-45)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T231956 WP_003156187.1 NZ_CP090838:c3497123-3496773 [Bacillus amyloliquefaciens]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T231956 NZ_CP127024:1664857-1665318 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT231956 WP_003156188.1 NZ_CP090838:c3497410-3497129 [Bacillus amyloliquefaciens]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT231956 NZ_CP127024:1664530-1664844 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8


Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References