Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 3339658..3341108 Replicon chromosome
Accession NZ_CP090838
Organism Bacillus amyloliquefaciens strain TL106

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag LT978_RS16395 Protein ID WP_014304519.1
Coordinates 3340419..3341108 (-) Length 230 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag LT978_RS16390 Protein ID WP_014304520.1
Coordinates 3339658..3340407 (-) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT978_RS16355 (LT978_16350) 3335311..3335616 - 306 WP_014304473.1 hypothetical protein -
LT978_RS16360 (LT978_16355) 3335629..3335871 - 243 WP_041481827.1 helix-turn-helix transcriptional regulator -
LT978_RS16365 (LT978_16360) 3336041..3336421 + 381 WP_013351190.1 helix-turn-helix domain-containing protein -
LT978_RS16370 (LT978_16365) 3336710..3337270 + 561 WP_053574359.1 DUF4352 domain-containing protein -
LT978_RS16375 (LT978_16370) 3337454..3337927 + 474 WP_041481826.1 ImmA/IrrE family metallo-endopeptidase -
LT978_RS16380 (LT978_16375) 3337939..3339150 + 1212 WP_139890492.1 site-specific integrase -
LT978_RS16385 (LT978_16380) 3339435..3339623 + 189 WP_041481838.1 hypothetical protein -
LT978_RS16390 (LT978_16385) 3339658..3340407 - 750 WP_014304520.1 DUF4065 domain-containing protein Antitoxin
LT978_RS16395 (LT978_16390) 3340419..3341108 - 690 WP_014304519.1 hypothetical protein Toxin
LT978_RS16400 (LT978_16395) 3341433..3342404 - 972 WP_252616862.1 N-acetylmuramoyl-L-alanine amidase -
LT978_RS16405 (LT978_16400) 3342451..3342873 - 423 WP_014304517.1 phage holin family protein -
LT978_RS16410 (LT978_16405) 3342908..3343129 - 222 WP_252616864.1 hypothetical protein -
LT978_RS16415 (LT978_16410) 3343143..3343310 - 168 WP_014471524.1 XkdX family protein -
LT978_RS16420 (LT978_16415) 3343329..3343616 - 288 WP_119027021.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 3290163..3382935 92772


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(100-215)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 230 a.a.        Molecular weight: 27501.42 Da        Isoelectric Point: 8.1662

>T231955 WP_014304519.1 NZ_CP090838:c3341108-3340419 [Bacillus amyloliquefaciens]
MIKCTCRIESFCNHLHQLILEINQLHSDFSTNFSLKQDVKHVHLKKTQIRHVTEVTEKRNIFSIDNDFFILLQHYADKLE
DIVIYNDLEYLYSEFDLRLRVKQPDSIVNKLKYYRVGKKESGQIALRKCLNDLLGIRITIDSFDHNNKCFQDMCELLKKQ
YKINCMDSSKGDYKAFHFYFYGESTFFFPWELQIWRTDDKEANNRSHQLHKQAYKGWASIYKNSTEVEK

Download         Length: 690 bp

>T231955 NZ_CP127024:957401-957694 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28795.94 Da        Isoelectric Point: 6.4113

>AT231955 WP_014304520.1 NZ_CP090838:c3340407-3339658 [Bacillus amyloliquefaciens]
MAFHFIAIISDFSGGRRMGWHYSSEERLDKNYISDFFERVKEKCGMVQFGIHKLSTDSTSWKSVTEKDSFFDDVYVTEDI
STFIDVISKDKELTAYDVAKFVLSFKPASHLKLQKLLYYIYAEFLLKTGEKLFKEPIVAFKYGPVIESIFYKYKTHGKSE
IDYEEDASIKLRTDDVVITPSFMKILSSEYGIEALGCIIEVLVKYGRYSAFGLVEKTHQDGGPWHRVYKPGQNCVITDEL
ITQYHQHAL

Download         Length: 750 bp

>AT231955 NZ_CP127024:957189-957398 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References