Detailed information of TA system TA231952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 2856804..2857369
• Replicon: chromosome
• Accession: NZ_CP090837
• Organism: Streptomyces sp. R527F

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LZ559_RS12700
• Protein ID: WP_234876737.1
• Coordinates: 2856804..2857172 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Q5BHI7
• Locus tag: LZ559_RS12705
• Protein ID: WP_044373773.1
• Coordinates: 2857172..2857369 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ559_RS12685 (LZ559_12685)	2852779..2853567	-	789	WP_073777223.1	S16 family serine protease	-
LZ559_RS12690 (LZ559_12690)	2853721..2854365	-	645	WP_006124906.1	helix-turn-helix domain-containing protein	-
LZ559_RS12695 (LZ559_12695)	2854850..2856634	-	1785	WP_032793775.1	DEAD/DEAH box helicase	-
LZ559_RS12700 (LZ559_12700)	2856804..2857172	-	369	WP_234876737.1	Fic family protein	Toxin
LZ559_RS12705 (LZ559_12705)	2857172..2857369	-	198	WP_044373773.1	Arc family DNA-binding protein	Antitoxin
LZ559_RS12710 (LZ559_12710)	2857405..2858916	-	1512	WP_030802545.1	MFS transporter	-
LZ559_RS12720 (LZ559_12720)	2859268..2860035	-	768	WP_044373771.1	hypothetical protein	-
LZ559_RS12725 (LZ559_12725)	2860100..2860771	-	672	WP_030802543.1	hypothetical protein	-
LZ559_RS12730 (LZ559_12730)	2860768..2861415	-	648	WP_234876738.1	hypothetical protein	-
LZ559_RS12735 (LZ559_12735)	2861489..2861992	-	504	WP_128862769.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (12-118)

Antitoxin

• Arc-like DNA binding domain (5-28)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13687.57 Da
• Isoelectric Point: 4.5341

>T231952 WP_234876737.1 NZ_CP090837:c2857172-2856804 [Streptomyces sp. R527F]
MQYLTLPELLNLTERLGTPEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWYATWVFL
HMNGHQLDAGFDVDEAERFVPAVCQGALDMPKIAEQLPEFAR

Nucleotide

• Length: 369 bp

>T231952 NZ_CP127021:c2686742-2686476 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7309.13 Da
• Isoelectric Point: 4.7860

>AT231952 WP_044373773.1 NZ_CP090837:c2857369-2857172 [Streptomyces sp. R527F]
MAGLNLRFTEEELDSLRARAEAEGRSMQAFAHDAVITAVNEHSRLFDEAADHVLKVSEELNRRLA

Nucleotide

• Length: 198 bp

>AT231952 NZ_CP127021:c2686993-2686742 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q5BHI7