Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4668318..4668937 Replicon chromosome
Accession NZ_CP090834
Organism Klebsiella pneumoniae strain K-28

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L0U94_RS23075 Protein ID WP_002892050.1
Coordinates 4668719..4668937 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L0U94_RS23070 Protein ID WP_002892066.1
Coordinates 4668318..4668692 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0U94_RS23060 (L0U94_23035) 4663470..4664663 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L0U94_RS23065 (L0U94_23040) 4664686..4667832 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
L0U94_RS23070 (L0U94_23045) 4668318..4668692 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L0U94_RS23075 (L0U94_23050) 4668719..4668937 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L0U94_RS23080 (L0U94_23055) 4669096..4669662 + 567 WP_002892030.1 maltose O-acetyltransferase -
L0U94_RS23085 (L0U94_23060) 4669634..4669774 - 141 WP_004147370.1 hypothetical protein -
L0U94_RS23090 (L0U94_23065) 4669795..4670265 + 471 WP_002892026.1 YlaC family protein -
L0U94_RS23095 (L0U94_23070) 4670240..4671691 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
L0U94_RS23100 (L0U94_23075) 4671792..4672490 + 699 WP_002892021.1 GNAT family protein -
L0U94_RS23105 (L0U94_23080) 4672487..4672627 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L0U94_RS23110 (L0U94_23085) 4672627..4672890 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T231945 WP_002892050.1 NZ_CP090834:4668719-4668937 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T231945 NZ_CP127021:c940078-939890 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT231945 WP_002892066.1 NZ_CP090834:4668318-4668692 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT231945 NZ_CP127021:c940367-940107 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References