Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 3610827..3611539 Replicon chromosome
Accession NC_011386
Organism Oligotropha carboxidovorans OM5

Toxin (Protein)


Gene name vapC Uniprot ID B6JJZ4
Locus tag OCAR_RS17115 Protein ID WP_012564773.1
Coordinates 3610827..3611264 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B6JJZ5
Locus tag OCAR_RS17120 Protein ID WP_012564774.1
Coordinates 3611261..3611539 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCAR_RS17095 3606144..3607127 - 984 WP_013913427.1 plasmid partitioning protein RepB -
OCAR_RS17100 3607124..3608347 - 1224 WP_012564770.1 plasmid partitioning protein RepA -
OCAR_RS17105 3608556..3609728 - 1173 WP_012564771.1 site-specific integrase -
OCAR_RS17110 3609742..3610830 - 1089 WP_012564772.1 hypothetical protein -
OCAR_RS17115 3610827..3611264 - 438 WP_012564773.1 type II toxin-antitoxin system VapC family toxin Toxin
OCAR_RS17120 3611261..3611539 - 279 WP_012564774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCAR_RS17125 3611662..3611976 + 315 WP_013913495.1 hypothetical protein -
OCAR_RS17130 3612228..3613424 + 1197 WP_012564775.1 DUF1612 and helix-turn-helix domain-containing protein -
OCAR_RS17135 3613553..3614539 + 987 WP_012564776.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(13-59)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15898.26 Da        Isoelectric Point: 4.6115

>T23194 WP_012564773.1 NC_011386:c3611264-3610827 [Afipia carboxidovorans OM5]
MNVLLDTNVLSEVRRPAPDPKVLAWLDAIDEDRAFISVTSIAELRRGIALMDDGRRREALTAWLAEDLPARFAGRILPID
PAIAARWGDLMAHARQSGFALSVMDGFFAATALDRELMLATRNTKDFAPLGVPLLNPWTDEGVSG

Download         Length: 438 bp

>T23194 NC_011386:c3611264-3610827 [Afipia carboxidovorans OM5]
ATGAATGTCCTGCTCGACACCAACGTGCTCTCCGAGGTTCGCCGGCCGGCGCCAGATCCGAAGGTGCTTGCCTGGCTCGA
TGCGATCGACGAGGACCGGGCCTTCATCAGCGTGACATCGATCGCCGAGCTCCGGCGCGGCATCGCCCTGATGGACGACG
GCCGCCGTCGCGAAGCGCTGACGGCCTGGCTCGCAGAGGATCTGCCGGCGCGTTTCGCCGGCCGGATCCTGCCGATCGAC
CCGGCGATCGCCGCACGCTGGGGCGATCTGATGGCACATGCCCGCCAGAGCGGCTTTGCCCTTTCGGTCATGGACGGGTT
TTTCGCAGCGACGGCTCTCGACCGCGAACTCATGCTCGCGACCCGCAACACCAAGGATTTTGCTCCGCTGGGCGTGCCGC
TGTTGAACCCCTGGACAGATGAAGGAGTCTCGGGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10337.67 Da        Isoelectric Point: 7.4057

>AT23194 WP_012564774.1 NC_011386:c3611539-3611261 [Afipia carboxidovorans OM5]
VTASRKTHAHESDHWTVAGAKARLSEVIERAQTDPQIITRHGKPSVVIVSAEEWARKTVRKGTLAEFLMASPLRDADLDL
DRVRDQPRDLDL

Download         Length: 279 bp

>AT23194 NC_011386:c3611539-3611261 [Afipia carboxidovorans OM5]
GTGACAGCCTCCCGCAAAACCCACGCCCACGAATCGGATCATTGGACGGTTGCCGGCGCTAAAGCGCGCCTCTCCGAAGT
GATTGAGCGCGCCCAGACTGATCCGCAGATCATCACCCGCCACGGCAAGCCGAGCGTCGTCATCGTCTCGGCCGAGGAAT
GGGCGCGCAAGACCGTCCGCAAGGGGACCCTGGCCGAATTCCTGATGGCCTCGCCCCTGCGGGACGCCGATCTCGATCTC
GATCGGGTTCGCGATCAGCCGCGCGACCTTGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6JJZ4

Antitoxin

Source ID Structure
AlphaFold DB B6JJZ5

References