Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1462582..1463239 Replicon chromosome
Accession NZ_CP090834
Organism Klebsiella pneumoniae strain K-28

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L0U94_RS07230 Protein ID WP_002916310.1
Coordinates 1462829..1463239 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L0U94_RS07225 Protein ID WP_002916312.1
Coordinates 1462582..1462848 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0U94_RS07200 (L0U94_07195) 1457738..1459171 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L0U94_RS07205 (L0U94_07200) 1459290..1460018 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L0U94_RS07210 (L0U94_07205) 1460068..1460379 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
L0U94_RS07215 (L0U94_07210) 1460543..1461202 + 660 WP_002916317.1 hemolysin III family protein -
L0U94_RS07220 (L0U94_07215) 1461353..1462336 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L0U94_RS07225 (L0U94_07220) 1462582..1462848 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L0U94_RS07230 (L0U94_07225) 1462829..1463239 + 411 WP_002916310.1 protein YgfX Toxin
L0U94_RS07235 (L0U94_07230) 1463246..1463767 - 522 WP_002916308.1 flavodoxin FldB -
L0U94_RS07240 (L0U94_07235) 1463868..1464764 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L0U94_RS07245 (L0U94_07240) 1464787..1465500 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0U94_RS07250 (L0U94_07245) 1465506..1467239 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T231935 WP_002916310.1 NZ_CP090834:1462829-1463239 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T231935 NZ_CP127019:c2061629-2061477 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT231935 WP_002916312.1 NZ_CP090834:1462582-1462848 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT231935 NZ_CP127019:c2062253-2061654 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References