Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1326963..1327738 Replicon chromosome
Accession NZ_CP090834
Organism Klebsiella pneumoniae strain K-28

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag L0U94_RS06510 Protein ID WP_004150910.1
Coordinates 1327253..1327738 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag L0U94_RS06505 Protein ID WP_004150912.1
Coordinates 1326963..1327256 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0U94_RS06485 (L0U94_06480) 1322171..1322773 - 603 WP_002916735.1 short chain dehydrogenase -
L0U94_RS06490 (L0U94_06485) 1322871..1323782 + 912 WP_004188550.1 LysR family transcriptional regulator -
L0U94_RS06495 (L0U94_06490) 1323783..1324931 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
L0U94_RS06500 (L0U94_06495) 1324942..1326318 - 1377 WP_004217775.1 cystathionine beta-synthase -
L0U94_RS06505 (L0U94_06500) 1326963..1327256 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
L0U94_RS06510 (L0U94_06505) 1327253..1327738 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
L0U94_RS06515 (L0U94_06510) 1328442..1329035 + 594 WP_004188553.1 hypothetical protein -
L0U94_RS06520 (L0U94_06515) 1329132..1329348 + 217 Protein_1259 transposase -
L0U94_RS06530 (L0U94_06525) 1331263..1332135 + 873 WP_004188557.1 ParA family protein -
L0U94_RS06535 (L0U94_06530) 1332135..1332518 + 384 WP_004150906.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T231934 WP_004150910.1 NZ_CP090834:1327253-1327738 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T231934 NZ_CP127019:2003547-2003642 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT231934 WP_004150912.1 NZ_CP090834:1326963-1327256 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT231934 NZ_CP127019:c2003729-2003670 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References