Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 23654..24170 Replicon chromosome
Accession NZ_CP090834
Organism Klebsiella pneumoniae strain K-28

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag L0U94_RS00120 Protein ID WP_002886902.1
Coordinates 23654..23938 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L0U94_RS00125 Protein ID WP_002886901.1
Coordinates 23928..24170 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0U94_RS00095 (L0U94_00090) 19138..19401 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
L0U94_RS00100 (L0U94_00095) 19531..19704 + 174 WP_002886906.1 hypothetical protein -
L0U94_RS00105 (L0U94_00100) 19707..20450 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L0U94_RS00110 (L0U94_00105) 20807..22945 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
L0U94_RS00115 (L0U94_00110) 23186..23650 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0U94_RS00120 (L0U94_00115) 23654..23938 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0U94_RS00125 (L0U94_00120) 23928..24170 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0U94_RS00130 (L0U94_00125) 24248..26158 - 1911 WP_004152270.1 PRD domain-containing protein -
L0U94_RS00135 (L0U94_00130) 26181..27335 - 1155 WP_002886900.1 lactonase family protein -
L0U94_RS00140 (L0U94_00135) 27401..28141 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T231929 WP_002886902.1 NZ_CP090834:c23938-23654 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T231929 NZ_CP127017:c2494598-2494332 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT231929 WP_002886901.1 NZ_CP090834:c24170-23928 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT231929 NZ_CP127017:c2494855-2494598 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References