Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3800072..3800729 Replicon chromosome
Accession NZ_CP090796
Organism Enterobacter hormaechei strain Y-2

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag L0Y15_RS17895 Protein ID WP_022649305.1
Coordinates 3800072..3800482 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag L0Y15_RS17900 Protein ID WP_003863437.1
Coordinates 3800463..3800729 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y15_RS17875 (L0Y15_17875) 3796070..3797803 - 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -
L0Y15_RS17880 (L0Y15_17880) 3797809..3798522 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0Y15_RS17885 (L0Y15_17885) 3798551..3799447 - 897 WP_022651809.1 site-specific tyrosine recombinase XerD -
L0Y15_RS17890 (L0Y15_17890) 3799549..3800070 + 522 WP_003863440.1 flavodoxin FldB -
L0Y15_RS17895 (L0Y15_17895) 3800072..3800482 - 411 WP_022649305.1 protein YgfX Toxin
L0Y15_RS17900 (L0Y15_17900) 3800463..3800729 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
L0Y15_RS17905 (L0Y15_17905) 3801024..3802004 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
L0Y15_RS17910 (L0Y15_17910) 3802090..3802749 - 660 WP_003863433.1 hemolysin III family protein -
L0Y15_RS17915 (L0Y15_17915) 3803016..3803747 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
L0Y15_RS17920 (L0Y15_17920) 3803864..3805297 + 1434 WP_022651811.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T231928 WP_022649305.1 NZ_CP090796:c3800482-3800072 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T231928 NZ_CP127017:c2463030-2462923 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT231928 WP_003863437.1 NZ_CP090796:c3800729-3800463 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT231928 NZ_CP127017:2462846-2462906 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References