Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3112720..3114503 Replicon chromosome
Accession NZ_CP090796
Organism Enterobacter hormaechei strain Y-2

Toxin (Protein)


Gene name hipA Uniprot ID A0A8B5ZXW9
Locus tag L0Y15_RS14730 Protein ID WP_022651516.1
Coordinates 3112720..3114069 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag L0Y15_RS14735 Protein ID WP_003859317.1
Coordinates 3114066..3114503 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y15_RS14705 (L0Y15_14705) 3108543..3109478 - 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -
L0Y15_RS14710 (L0Y15_14710) 3109647..3110042 + 396 WP_003859308.1 CidA/LrgA family protein -
L0Y15_RS14715 (L0Y15_14715) 3110039..3110734 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
L0Y15_RS14720 (L0Y15_14720) 3110863..3111747 + 885 WP_022651515.1 cytidine deaminase -
L0Y15_RS14725 (L0Y15_14725) 3111875..3112585 + 711 WP_003859314.1 outer membrane permeability protein SanA -
L0Y15_RS14730 (L0Y15_14730) 3112720..3114069 + 1350 WP_022651516.1 HipA domain-containing protein Toxin
L0Y15_RS14735 (L0Y15_14735) 3114066..3114503 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y15_RS14740 (L0Y15_14740) 3114542..3115552 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
L0Y15_RS14745 (L0Y15_14745) 3115568..3117088 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
L0Y15_RS14750 (L0Y15_14750) 3117168..3118166 - 999 WP_003859322.1 galactose/glucose ABC transporter substrate-binding protein MglB -
L0Y15_RS14755 (L0Y15_14755) 3118462..3119484 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51151.85 Da        Isoelectric Point: 4.7049

>T231927 WP_022651516.1 NZ_CP090796:3112720-3114069 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKKDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T231927 NZ_CP127017:c2437760-2437494 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT231927 WP_003859317.1 NZ_CP090796:3114066-3114503 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT231927 NZ_CP127017:c2438011-2437760 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5ZXW9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References