Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2236640..2237379 Replicon chromosome
Accession NZ_CP090796
Organism Enterobacter hormaechei strain Y-2

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag L0Y15_RS10570 Protein ID WP_003857133.1
Coordinates 2236640..2237125 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag L0Y15_RS10575 Protein ID WP_003857131.1
Coordinates 2237113..2237379 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y15_RS10555 (L0Y15_10555) 2233507..2234940 - 1434 WP_004016055.1 restriction endonuclease -
L0Y15_RS10560 (L0Y15_10560) 2234961..2235764 - 804 WP_039268887.1 TIGR02391 family protein -
L0Y15_RS10565 (L0Y15_10565) 2235786..2236265 - 480 WP_001542736.1 hypothetical protein -
L0Y15_RS10570 (L0Y15_10570) 2236640..2237125 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
L0Y15_RS10575 (L0Y15_10575) 2237113..2237379 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
L0Y15_RS10580 (L0Y15_10580) 2237443..2238372 - 930 WP_022651200.1 LysR family transcriptional regulator -
L0Y15_RS10585 (L0Y15_10585) 2238502..2239890 + 1389 WP_032645625.1 MFS transporter -
L0Y15_RS10590 (L0Y15_10590) 2239912..2240907 - 996 WP_003857125.1 DUF2891 domain-containing protein -
L0Y15_RS10595 (L0Y15_10595) 2240917..2241903 - 987 WP_022651202.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2215629..2237379 21750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T231918 WP_003857133.1 NZ_CP090796:c2237125-2236640 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T231918 NZ_CP126994:c2684486-2684157 [Acidisoma sp. PAMC 29798]
TTGGATTGGTTCTACAAATTTGTAGTAACACGTGCTGTGAATGTTCGAGTAGAGTGGGATCCGGTCAAAGCCGATCAAAA
TCTGCGCAAGCACCGGGTCAGCTTCGCCTTGGCCATGCGCGTTTTCTTTGATCCTCTCGCTCTCGTCGAACAGGACCGCG
TCGAGGGCGGTGAAGAGCGTTGGCAGACACTTGGCATGGTCGATGGCGTGACGCTGCTGCTCGTCGCTCATACGATGTTG
GACGGCGGTGCCATCGAGGTGATCCGCATCATATCGGCTAGGCGCGCCGAGCCGAAGGAGAGGAGGAATTATGAGCAAGC
ACAGCGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT231918 WP_003857131.1 NZ_CP090796:c2237379-2237113 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT231918 NZ_CP126994:c2684176-2683865 [Acidisoma sp. PAMC 29798]
ATGAGCAAGCACAGCGTTAGGCGATTGGTCGACCTGTCCAGCCCACCGCCACTGACAGACGACGAACGGGCAGAACTCGC
CATCTTGAGTTCGATGCCGGATGACGAGATCGACACGAGCGATATTCCGCCTTTGACTGACGCCTTCTGGAAGGCTGCCG
TTCAGAATCCTTTCTATAAGCCGACCAAGACCTCGACGACCGTACGGATCGATTCGGATGTGCTCGCCTGGCTACGTGGG
CACGGCAAGGGCTATCAATCCCGGATCAACGCCATTCTCCGGCGTGAAATGCTGACCTCTCTCAAGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References