Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1101512..1102132 Replicon chromosome
Accession NZ_CP090796
Organism Enterobacter hormaechei strain Y-2

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag L0Y15_RS05190 Protein ID WP_015571250.1
Coordinates 1101512..1101730 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag L0Y15_RS05195 Protein ID WP_006809850.1
Coordinates 1101758..1102132 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y15_RS05160 (L0Y15_05160) 1097524..1097784 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
L0Y15_RS05165 (L0Y15_05165) 1097787..1097927 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
L0Y15_RS05170 (L0Y15_05170) 1097924..1098634 - 711 WP_022650493.1 GNAT family protein -
L0Y15_RS05175 (L0Y15_05175) 1098736..1100196 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
L0Y15_RS05180 (L0Y15_05180) 1100168..1100635 - 468 WP_022650495.1 YlaC family protein -
L0Y15_RS05185 (L0Y15_05185) 1100752..1101303 - 552 WP_126517401.1 maltose O-acetyltransferase -
L0Y15_RS05190 (L0Y15_05190) 1101512..1101730 - 219 WP_015571250.1 HHA domain-containing protein Toxin
L0Y15_RS05195 (L0Y15_05195) 1101758..1102132 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
L0Y15_RS05200 (L0Y15_05200) 1102643..1105789 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
L0Y15_RS05205 (L0Y15_05205) 1105812..1107005 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T231916 WP_015571250.1 NZ_CP090796:c1101730-1101512 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T231916 NZ_CP126994:c2555158-2554856 [Acidisoma sp. PAMC 29798]
ATGATCGACGTCCGGCAGACCTCGACCTTCTCTGACTGGCTCGATGGCGTTCGTGATCGGCCCGCGGGTCAGCGCATCAA
CCTGCGTATCCGACGCGTCTCGCTTGGCAATTTCGGTGATGTGAAACTGGTGGGAGAGGGCGTTTCGGAACTGCGGATCG
ACTACGGCCCAGGCTATCGCATCTATGTCAGGCGACGCGGCCTGACCGTTGTTCTGCTGCTGTGTGGCGGCGACAAATCG
ACGCAGGATCGCGACATCGCGCGCGCAAAGACTCTGGCAAAGGAAGACGACAATGGCGCTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT231916 WP_006809850.1 NZ_CP090796:c1102132-1101758 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT231916 NZ_CP126994:c2554866-2554561 [Acidisoma sp. PAMC 29798]
ATGGCGCTTGAGACGACGGGATGGGACCCCACCGACCAACTCCGCTCGCCCGAGGATGAGCAGGCCTACATAGAAGCCGC
CTTCGAGGAAGGCGACCCCGACCTCATCGCGGCCGCCATCGGTGACATTGCCCGCGCACGCGGCATGGCGCAGATCGCGC
GCGAAGCCGGTGTCAGCCGAGAGGCGATGTACAAGTCGTTCCGCGCCGGCGGTAACCCTACACTCGATACGGTCGCGCGT
GTCACAAGGGTGTTAGGCCTGCGACTGCTGGTGCGCCCGCAGCCGGAGCAGGATGCGTGTAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References