Detailed information of TA system TA231912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4920745..4921361
• Replicon: chromosome
• Accession: NZ_CP090792
• Organism: Enterobacter hormaechei strain FY-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Y16_RS23635
• Protein ID: WP_077266491.1
• Coordinates: 4920745..4921116 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: L0Y16_RS23640
• Protein ID: WP_015569912.1
• Coordinates: 4921119..4921361 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y16_RS23620 (L0Y16_23620)	4918245..4919147	+	903	WP_014072386.1	formate dehydrogenase subunit beta	-
L0Y16_RS23625 (L0Y16_23625)	4919144..4919779	+	636	WP_015569914.1	formate dehydrogenase cytochrome b556 subunit	-
L0Y16_RS23630 (L0Y16_23630)	4919776..4920705	+	930	WP_003861956.1	formate dehydrogenase accessory protein FdhE	-
L0Y16_RS23635 (L0Y16_23635)	4920745..4921116	-	372	WP_077266491.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Y16_RS23640 (L0Y16_23640)	4921119..4921361	-	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
L0Y16_RS23645 (L0Y16_23645)	4921560..4922480	+	921	WP_032652004.1	alpha/beta hydrolase	-
L0Y16_RS23650 (L0Y16_23650)	4922489..4923430	-	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
L0Y16_RS23655 (L0Y16_23655)	4923475..4923912	-	438	WP_015569909.1	D-aminoacyl-tRNA deacylase	-
L0Y16_RS23660 (L0Y16_23660)	4923909..4924790	-	882	WP_003861949.1	virulence factor BrkB family protein	-
L0Y16_RS23665 (L0Y16_23665)	4924784..4925383	-	600	WP_003861947.1	glucose-1-phosphatase	-
L0Y16_RS23670 (L0Y16_23670)	4925502..4926302	-	801	WP_003861944.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13723.85 Da
• Isoelectric Point: 6.4882

>T231912 WP_077266491.1 NZ_CP090792:c4921116-4920745 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T231912 NZ_CP126994:c1832937-1832629 [Acidisoma sp. PAMC 29798]
ATGGCAGGCATCCGCTTTGAATGGGATGAGGCGAAAAGCCGTTCTAATCAGAGAAAACACGGACTGAGTTTCGAGGAGGC
CAGTCAGGTGTTCAACGACCCCATGCATTTCTCGGTGCTTGATCGGATTGAAGGCCATGAATATCGCTGGCGTACTTTGG
GTCTGATCGGGGGCTTCATGATCCTGATGGTCGCCCACACGATGACTGAGACCGACGCCGAAGGCGATTCGATTGACGTC
ATTCGCATCATCTCGGCACGACGCGCCGACCGGATGGAAAGAAGACGGTATGAAAACGAAAACGGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT231912 WP_015569912.1 NZ_CP090792:c4921361-4921119 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT231912 NZ_CP126994:c1832648-1832346 [Acidisoma sp. PAMC 29798]
ATGAAAACGAAAACGGTTAGTTTTACTGCAACCACGCTGCCTCGCCTCACCGACGAGCAGAGGGCAAGCCTGACCTCTCT
GGCAGCACGCCCTGATAGCGAAATAGATTATAGCGACATACCAGAGATAACGGATGCGCAACTGAAGACCGGAGTCCGCG
GTCGCTTCTACAGACCGGTCAAGATGCAGATCACGGCGCGTGTCGATGCCGACGTTCTCGAATGGCTGAAGTCGCAAGGC
AAAGGGTATCAGGCGCGCTTGAATGCTATCCTGCGGCGCGAAATGCTCAACGCGCTTAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3